Wettergren L, Sprangers M, Björkholm M, Langius-Eklöf A
Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden.
Psychooncology. 2008 Apr;17(4):338-46. doi: 10.1002/pon.1240.
The aim was to prospectively measure quality of life in patients with malignant blood disorders following stem cell transplantation (SCT) using an individualized and a standardized measure.
Twenty-two consecutive patients were assessed before and one year following SCT, using a generic and disease-related version of the Schedule for the Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW) and the EORTC QLQ-C30. Results of the QLQ-C30 were compared with Swedish norm values.
A majority of the patients reported concerns related to health before as well as one year after SCT, recorded by both instruments. Mean scores produced by the SEIQoL-DW, and four scales of the EORTC QLQ-C30, showed a change over time, indicating improved quality of life one year after SCT. In comparison with Swedish norm values for the EORTC QLQ-C30, SCT recipients reported a worse functioning.
In addition to well-known disease and treatment-related problems, areas not typically included in standardized instruments were nominated in the disease-related SEIQoL-DW. Such areas included positive aspects, e.g. a changed view of life and oneself. The results support the use of the generic and disease-related SEIQoL-DW to achieve a comprehensive picture of patient's clinical situation under treatment or when recovering from illness.
旨在使用个体化和标准化测量方法对干细胞移植（SCT）后恶性血液病患者的生活质量进行前瞻性测量。
连续22例患者在SCT前及SCT后一年接受评估，使用通用版和疾病相关版的《个体生活质量评估量表 - 直接加权法》（SEIQoL - DW）以及欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ - C30）。将QLQ - C30的结果与瑞典常模值进行比较。
两种工具均记录显示，大多数患者在SCT前及SCT后一年均报告了与健康相关的担忧。SEIQoL - DW产生的平均得分以及EORTC QLQ - C30的四个量表显示随时间变化，表明SCT后一年生活质量有所改善。与EORTC QLQ - C30的瑞典常模值相比，SCT受者报告功能较差。
除了众所周知的与疾病和治疗相关的问题外，在疾病相关的SEIQoL - DW中还提到了标准化工具通常未包括的领域。这些领域包括积极方面，例如对生活和自身看法的改变。结果支持使用通用版和疾病相关版的SEIQoL - DW来全面了解患者在治疗期间或从疾病中康复时的临床情况。
