Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.

作者信息

Hoshino Yasutaka, Mukai Akira, Yazawa Katsukiyo, Uno Jun, Ando Akikazu, Mikami Yuzuru, Fukai Toshio, Ishikawa Jun, Yamaguchi Kentaro

机构信息

Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan.

出版信息

J Antibiot (Tokyo). 2004 Dec;57(12):803-7. doi: 10.7164/antibiotics.57.803.

DOI:10.7164/antibiotics.57.803

PMID:15745115

Abstract

A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.

摘要