Nonami Y, Moriki T
Department of Surgery II, Kochi Medical School, Kohasu Nankoku, Kochi 783-8505, Japan.
J Cardiovasc Surg (Torino). 2004 Dec;45(6):585-7.
A case of synchronous multiple thymomas is reported. The patient was an 81-year-old woman with 2 separate thymomas in the anterior mediastinum. A histological study revealed that both thymomas consisted of dense lymphocyte infiltration in the stroma and a small number of polygonal epithelial tumor cells with clear nuclei and distinct nucleoli. Immunohistochemical staining using the antibodies to 2 antigens, bcl-2, and MIB-1 showed identical staining patterns. In spite of these findings, we considered their origin to be synchronous multicentric development rather than intra-thymic metastasis, based on the non-invasive nature of these tumors.
本文报告了一例同步性多发性胸腺瘤病例。患者为一名81岁女性，前纵隔有两个独立的胸腺瘤。组织学研究显示，两个胸腺瘤均表现为间质内密集的淋巴细胞浸润，以及少量细胞核清晰、核仁明显的多边形上皮肿瘤细胞。使用针对bcl-2和MIB-1这两种抗原的抗体进行免疫组化染色，结果显示染色模式相同。尽管有这些发现，但基于这些肿瘤的非侵袭性，我们认为它们的起源是同步多中心发展，而非胸腺内转移。
