Nomori H, Kobayashi K, Ishihara T, Suito T, Torikata C
Department of Surgery, School of Medicine, Keio University, Tokyo.
Jpn J Clin Oncol. 1990 Jun;20(2):209-11. doi: 10.1093/oxfordjournals.jjco.a039389.
A case of multiple thymoma is reported. The patient was a 28-year-old woman who came to us with myasthenia gravis. There were two separate thymoma in the anterior mediastinum: one measured 70 x 30 x 30 mm, while the other was 1.5 mm in diameter and situated in the surrounding thymic tissue. A histological study revealed that both thymoma consisted of epithelial cells with abundant cytoplasm, round-to-oval nuclei and inconspicuous nucleoli. Morphometric analysis showed the nuclear size of the epithelial cells to be similar in both tumors. The likelihood of positive Leu7 and keratin immunohistochemical staining was also similar for the two tumors. The two thymoma had similar histological, morphometric and immunohistochemical characteristics. These findings suggest the possibility of intra-thymic metastasis rather than a multicentric thymoma development. Extended thymectomy should be performed for thymoma to prevent postoperative tumor recurrence.
报告了一例多发性胸腺瘤病例。患者为一名28岁女性，因重症肌无力前来就诊。前纵隔有两个独立的胸腺瘤：一个大小为70×30×30毫米，另一个直径为1.5毫米，位于周围的胸腺组织中。组织学研究显示，两个胸腺瘤均由上皮细胞组成，这些上皮细胞胞质丰富，细胞核呈圆形至椭圆形，核仁不明显。形态计量分析表明，两个肿瘤中上皮细胞的核大小相似。两种肿瘤Leu7和角蛋白免疫组化染色阳性的可能性也相似。这两个胸腺瘤具有相似的组织学、形态计量学和免疫组化特征。这些发现提示胸腺内转移的可能性，而非多中心胸腺瘤的发生。对于胸腺瘤应行扩大胸腺切除术以防止术后肿瘤复发。
