Dietz R, Schwarze G
Service de Radiologie/Centre Hospitalier de Luxembourg.
Strahlenther Onkol. 1992 Apr;168(4):240-3.
The effect of the cellular immune response by total body irradiation was investigated. The transplant survival (skin grafts) was determined as immune parameter. Donors were colony-bred Wistar rats and recipients were colony-bred Sprague-Dawley rats. The investigations were carried out with irradiated rats and with rats irradiated after thymectomy and/or adrenalectomy as well as with animals without irradiation. A single total-body irradiation (1 and 2 Gy) was administered. The skin graft survival in irradiated rats was significant shorter (radiogenic immunostimulation) than in unirradiated rats; there were no significant differences between the operated (thymectomy and/or adrenalectomy) and not operated animals. Including precedent examinations this radiogenic immunostimulation is caused by a relatively selective inactivation of T-suppressor cells.
研究了全身照射对细胞免疫反应的影响。将移植存活（皮肤移植）作为免疫参数进行测定。供体为群体饲养的Wistar大鼠，受体为群体饲养的Sprague-Dawley大鼠。对受照射大鼠、胸腺切除和/或肾上腺切除后受照射的大鼠以及未受照射的动物进行了研究。进行了单次全身照射（1和2 Gy）。受照射大鼠的皮肤移植存活时间明显短于未受照射大鼠（辐射性免疫刺激）；手术（胸腺切除和/或肾上腺切除）组与未手术动物之间无显著差异。结合先前的检查，这种辐射性免疫刺激是由T抑制细胞的相对选择性失活引起的。
