Dietz R, Schwarze G, Neu B
Strahlentherapie. 1983 Oct;159(10):629-32.
Comparative experimentations were performed on Sprague-Dawley rats in order to study the immunostimulation by whole-body irradiation with 60Co gamma radiation (doses between 0.5 and 2 Gy) or application of vincristine sulphate (doses between 1.5 and 6 micrograms per 100 g body weight). The primary production of antibodies against erythrocytes of sheep was determined as immunity parameter. An immunostimulation was observed in all experiments. The irradiated groups showed the highest stimulation after 1 Gy, and the most stimulating dose of vincristine was 6 micrograms/100 g body weight. The radiogenic stimulation was more significant. As a reason for these stimulations, the authors suppose the different sensitivity of individual lymphocyte populations participating in the induction of the humoral immune response which leads to a relatively greater inactivation of T suppressor lymphocytes.
为了研究60Coγ射线全身照射（剂量在0.5至2 Gy之间）或应用硫酸长春新碱（剂量在每100克体重1.5至6微克之间）对免疫的刺激作用，对Sprague-Dawley大鼠进行了对比实验。以针对绵羊红细胞的抗体的初级产生作为免疫参数。在所有实验中均观察到免疫刺激作用。照射组在1 Gy后显示出最高的刺激作用，而长春新碱的最大刺激剂量为6微克/100克体重。辐射诱导的刺激更为显著。作为这些刺激的原因，作者推测参与体液免疫反应诱导的各个淋巴细胞群体的敏感性不同，这导致T抑制淋巴细胞相对更大程度的失活。
