Cherubini Antonio, Martin Antonio, Andres-Lacueva Cristina, Di Iorio Angelo, Lamponi Marco, Mecocci Patrizia, Bartali Benedetta, Corsi Annamaria, Senin Umberto, Ferrucci Luigi
Institute of Gerontology and Geriatrics, University of Perugia Medical School, Department of Clinical and Experimental Medicine, via Brunamonti, Policlinico Monteluce, Padiglione E, Perugia 06122, Italy.
Neurobiol Aging. 2005 Jul;26(7):987-94. doi: 10.1016/j.neurobiolaging.2004.09.002. Epub 2004 Nov 5.
There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.
关于抗氧化剂有助于维持老年受试者认知功能的证据存在矛盾。在意大利进行的一项基于人群的队列研究中，我们调查了血浆维生素E水平是否与痴呆症和认知障碍的存在有关。共有1033名年龄至少65岁的参与者接受了临床和神经心理学检查，捐献血液用于维生素E分析，并对他们的饮食进行了评估。在对年龄、性别、教育程度、血脂水平、能量摄入、维生素E摄入量和吸烟情况进行调整后，与血浆维生素E水平处于最高三分位数的参与者相比，处于最低三分位数的参与者患痴呆症的可能性显著更高（比值比2.6，95%置信区间1.0 - 7.1），患认知障碍的可能性也更高（比值比2.2，95%置信区间1.2 - 4.2）。这项研究支持了较高的血浆维生素E水平可能为老年受试者预防认知障碍和痴呆症提供显著保护的观点。
