Burke Sara N, Chawla Monica K, Penner Marsha R, Crowell Brynne E, Worley Paul F, Barnes Carol A, McNaughton Bruce L
Neural Systems, Memory, and Aging Division, Life Sciences North Building, Room 384, University of Arizona, Tucson, AZ 85724, USA.
Neuron. 2005 Mar 3;45(5):667-74. doi: 10.1016/j.neuron.2005.01.042.
Rodent hippocampal activity is correlated with spatial and behavioral context, but how context affects coding in association neocortex is not well understood. The cellular distribution of the neural activity-regulated immediate-early gene Arc was used to monitor the activity history of cells in CA1, and in deep and superficial layers of posterior parietal and gustatory cortices (which encode movement and taste, respectively), during two behavioral epochs in which spatial and behavioral context were independently manipulated while gustatory input was held constant. Under conditions in which the hippocampus strongly differentiated behavioral and spatial contexts, deep parietal and gustatory layers did not discriminate between spatial contexts, whereas superficial layers in both neocortical regions discriminated well. Deep parietal cells discriminated behavioral context, whereas deep gustatory cortex neurons encoded the two conditions identically. Increased context sensitivity of superficial neocortical layers, which receive more hippocampal outflow, may reflect a general principle of neocortical organization for memory retrieval.
啮齿动物海马体活动与空间和行为背景相关，但背景如何影响联合新皮层中的编码尚不清楚。神经活动调节的即刻早期基因Arc的细胞分布被用于监测CA1以及后顶叶和味觉皮层深层和浅层（分别编码运动和味觉）细胞在两个行为阶段的活动历史，在这两个阶段中，空间和行为背景被独立操纵，而味觉输入保持恒定。在海马体强烈区分行为和空间背景的条件下，顶叶深层和味觉层无法区分空间背景，而两个新皮层区域的浅层则能很好地区分。顶叶深层细胞能区分行为背景，而味觉皮层深层神经元对两种情况的编码相同。接受更多海马体输出的新皮层浅层对背景的敏感性增加，这可能反映了新皮层组织用于记忆检索的一般原则。
