Faraut Brice, Andrillon Thomas, Drogou Catherine, Gauriau Caroline, Dubois Alexandre, Servonnet Aurélie, Van Beers Pascal, Guillard Mathias, Gomez-Merino Danielle, Sauvet Fabien, Chennaoui Mounir, Léger Damien
EA 7330 VIFASOM (Vigilance Fatigue Sommeil et Santé Publique), Université de Paris, Paris, France.
Consultation de Pathologie Professionnelle Sommeil Vigilance et Travail, Centre du Sommeil et de la Vigilance, Hôtel-Dieu, APHP-5, Paris, France.
Front Neurosci. 2020 Jan 8;13:1366. doi: 10.3389/fnins.2019.01366. eCollection 2019.
Sleep debt is becoming a better acknowledged cause of physiological stress and neurobehavioral deficits with major public-health concerns. We investigated whether exposure to blue light during daytime could be an efficient countermeasure to limit sleep restriction's impact on relevant behavioral (stress, sleepiness, sustained attention, and memory performance) and physiological (saliva cortisol, testosterone, and alpha-amylase) markers. Our semi-ecological, crossover, randomized design included 17 young men that underwent two sleep-restricted nights (3 h each) followed or not by blue light exposure (30-min-long sessions at 100 lux repeated four times throughout the day). Behavioral and physiological measurements were performed in the lab but outside these periods the participants kept following their usual routine. After sleep restriction, morning cortisol and testosterone, and afternoon alpha-amylase levels decreased. In parallel, subjective ratings of stress and sleepiness increased while performance on the sustained attention and memory tasks deteriorated. In contrast, after periods of blue light exposure, all these parameters were largely restored to baseline levels, despite an identical sleep restriction procedure, although this restorative effect was reduced for the memory task. Our findings suggest that even short exposure to blue light could trigger persistent beneficial effects throughout the day and could be potentially efficient in real-life settings.
睡眠债正日益成为一个受到更多关注的、引发生理应激和神经行为缺陷的原因，这引发了重大的公共卫生问题。我们研究了白天暴露于蓝光下是否可能成为一种有效的应对措施，以限制睡眠限制对相关行为（应激、嗜睡、持续注意力和记忆表现）和生理（唾液皮质醇、睾酮和α-淀粉酶）指标的影响。我们的半生态、交叉、随机设计纳入了17名年轻男性，他们经历了两个睡眠受限的夜晚（每晚3小时），之后有无蓝光暴露（全天重复4次，每次30分钟，光照强度为100勒克斯）。行为和生理测量在实验室进行，但在这些时间段之外，参与者保持日常作息。睡眠限制后，早晨的皮质醇和睾酮水平以及下午的α-淀粉酶水平下降。与此同时，应激和嗜睡的主观评分增加，而持续注意力和记忆任务的表现变差。相比之下，在蓝光暴露期之后，尽管睡眠限制程序相同，但所有这些参数在很大程度上恢复到了基线水平，不过记忆任务的这种恢复效果有所降低。我们的研究结果表明，即使是短时间暴露于蓝光下也可能在一整天内引发持续的有益影响，并且在现实生活环境中可能具有潜在的有效性。
