血管生成抑制因子可预防鸡胚绒毛尿囊膜中子宫内膜异位样病变的发展。
Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane.
作者信息
Nap Annemiek W, Dunselman Gerard A J, Griffioen Arjan W, Mayo Kevin H, Evers Johannes L H, Groothuis Patrick G
机构信息
Department of Obstetrics and Gynaecology, Research Institute Growth and Development (GROW), Maastricht University and University Hospital, Maastricht, The Netherlands.
出版信息
Fertil Steril. 2005 Mar;83(3):793-5. doi: 10.1016/j.fertnstert.2004.06.080.
A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.
进行了一项前瞻性研究，以确定血管生成抑制化合物抗人血管内皮生长因子（hVEGF）抗体、TNP-470、内皮抑素和血管抑素对鸡胚绒毛尿囊膜模型中血管生成及子宫内膜样病变形成的影响。用血管生成抑制药物治疗后，子宫内膜样病变的形成受到显著抑制，这与周围绒毛尿囊膜中血管密度降低以及子宫内膜样病变中更多坏死有关。
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