Choi Yeon-Joo, Jang Won-Jong, Kim Jong-Hyun, Ryu Ji-Sun, Lee Seung-Hyun, Park Kyung-Hee, Paik Hyung-Suk, Koh Young-Sang, Choi Myung-Sik, Kim Ik-Sang
Konkuk University, Choongbuk, Republic of Korea.
Pusan National University, Pusan, Republic of Korea.
Emerg Infect Dis. 2005 Feb;11(2):237-244. doi: 10.3201/eid1102.040603.
The presence of the nucleic acid of the spotted fever group (SPG) and typhus group (TG) rickettsiae was investigated in 200 serum specimens seropositive for SFG rickettsiae by multiplex-nested polymerase chain reaction with primers derived from the rickettsial outer membrane protein B gene. The DNA of SFG, TG, or both rickettsiae was amplified in the 24 serum specimens, and sequence analysis showed Rickettsia conorii, R. japonica, and R. felis in the specimens. R. conorii and R. typhi were found in 7 serum specimens, which indicated the possibility of dual infection in these patients. These findings suggest that several kinds of rickettsial diseases, including boutonneuse fever, rickettsialpox, R. felis infection, and Japanese spotted fever, as well as scrub typhus and murine typhus, are occurring in Korea.
采用源自立克次氏体外膜蛋白B基因的引物，通过多重巢式聚合酶链反应，对200份血清学检测呈斑点热群（SPG）立克次氏体血清阳性的标本进行了斑点热群和斑疹伤寒群立克次氏体核酸检测。在24份血清标本中扩增出了斑点热群、斑疹伤寒群或二者的立克次氏体DNA，序列分析显示标本中存在康氏立克次氏体、日本立克次氏体和猫立克次氏体。在7份血清标本中发现了康氏立克次氏体和伤寒立克次氏体，这表明这些患者存在双重感染的可能性。这些发现提示，韩国正在发生多种立克次氏体病，包括南欧斑疹热、立克次氏体痘、猫立克次氏体感染、日本斑点热，以及恙虫病和鼠型斑疹伤寒。
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