在肯尼亚西部恶性疟原虫流行地区居住的婴儿中，胎盘疟疾会削弱其针对恶性疟原虫表位的抗体反应的发育。
Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemic.
作者信息
Bonner Phillip Cullison, Zhou Zhiyong, Mirel Lisa B, Ayisi John G, Shi Ya Ping, van Eijk Anna M, Otieno Juliana A, Nahlen Bernard L, Steketee Richard W, Udhayakumar Venkatachalam
机构信息
Malaria Branch, Division of Parasitic Diseases, NCID, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
出版信息
Clin Diagn Lab Immunol. 2005 Mar;12(3):375-9. doi: 10.1128/CDLI.12.3.375-379.2005.
Abstract
To determine the effect of placental malaria (PM) infection on the development of antibody responses to malaria in infants, we measured immunoglobulin G levels to seven different Plasmodium falciparum epitopes by using plasma samples collected at monthly intervals from infants born to mothers with and without PM. Overall, PM was associated with diminished antibody levels to all of the epitopes tested, especially with infants aged >or=4 to 12 months, and the difference was statistically significant for four of the seven epitopes (P<0.0035). These findings suggest that PM can negatively influence the development of immune responses to malaria in infants.
摘要
为确定胎盘疟疾（PM）感染对婴儿疟疾抗体反应发育的影响，我们使用从患有和未患PM的母亲所生婴儿每月采集的血浆样本，测量了针对七种不同恶性疟原虫表位的免疫球蛋白G水平。总体而言，PM与所有测试表位的抗体水平降低有关，尤其是对于年龄≥4至12个月的婴儿，并且在七种表位中有四种表位的差异具有统计学意义（P<0.0035）。这些发现表明，PM可对婴儿疟疾免疫反应的发育产生负面影响。
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