Among the nation's health plans, Aetna is considered the industry leader in efforts to eliminate racial and ethnic disparities in health care. This Perspective describes the work of a task force led by Aetna's chairman and CEO, charged with a number of strategic activities including cultural competency training and the identification of disparities occurring within the Aetna membership population. The cornerstone of this quality-of-care initiative is a successful and ongoing data collection enterprise. Aetna is putting the data to work in its chronic disease management, breast health, and African American Preterm Labor Prevention and Breastfeeding programs.