丁溴东莨菪碱（解痉灵）栓剂作为分娩时宫颈解痉剂的疗效。
Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour.
作者信息
Sirohiwal Daya, Dahiya Krishna, De Mandira
机构信息
Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Sciences, Haryana, India.
出版信息
Aust N Z J Obstet Gynaecol. 2005 Apr;45(2):128-9. doi: 10.1111/j.1479-828X.2005.00359.x.
OBJECTIVE
To evaluate the efficacy and safety of hyoscine-N-butyl bromide (Buscopan) suppositories in the active phase of labour, i.e. once the labour is established.
METHODS
A non-randomised controlled prospective study was carried out on 200 women in labour. In the active phase of labour, at 3 cm or more cervical dilatation, 100 women were administered Buscopan via suppository and 100 women (control) were not given any drug.
RESULTS
The duration of first stage of labour was 123.86 +/- 68.89 (mean(+)-standard deviation) minutes in the study group and 368.05 +/- 133.0 min in the control group. These differences were statistically significant. There were no differences in the duration of the second and third stages of labour. There was no increased incidence of operative deliveries in the study group. No adverse effects were noted on the mother or fetus.
CONCLUSION
Hyoscine-N-butyl bromide (HBB, Buscopan) suppositories were highly effective in shortening the duration of the first stage of labour.
目的
评估丁溴东莨菪碱（解痉灵）栓剂在产程活跃期，即分娩确立后的疗效及安全性。
方法
对200名分娩女性进行了一项非随机对照前瞻性研究。在产程活跃期，宫颈扩张达3厘米或以上时，100名女性经栓剂给予解痉灵，100名女性（对照组）未给予任何药物。
结果
研究组第一产程时长为123.86±68.89（均值±标准差）分钟，对照组为368.05±133.0分钟。这些差异具有统计学意义。第二和第三产程时长无差异。研究组手术分娩发生率未增加。未观察到对母亲或胎儿的不良影响。
结论
丁溴东莨菪碱（HBB，解痉灵）栓剂在缩短第一产程时长方面非常有效。
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