Fokas S, Fokas S, Tsironi M, Kalkani M, Dionysopouloy M
Sparta General Hospital, Microbiology, Sparta, Laconia, Greece.
Clin Microbiol Infect. 2005 Apr;11(4):337-40. doi: 10.1111/j.1469-0691.2005.01101.x.
Between January 2002 and December 2003, macrolide-resistant isolates of Staphylococcus aureus (n = 45) and coagulase-negative staphylococci (CoNS; n = 75) from a Greek hospital were examined phenotypically for inducible clindamycin resistance. The constitutive macrolide resistance phenotype predominated (60%) in S. aureus, followed by the inducible (35%) and the clindamycin-susceptible (5%) phenotypes. In CoNS, the inducible phenotype was more common than the constitutive phenotype (50% vs. 41%). There was a significant incidence of inducible clindamycin resistance, and screening of all staphylococci is necessary in order to differentiate inducibly resistant isolates from those that are truly sensitive.
2002年1月至2003年12月期间，对一家希腊医院的耐大环内酯类金黄色葡萄球菌（n = 45）和凝固酶阴性葡萄球菌（CoNS；n = 75）分离株进行了诱导型克林霉素耐药性的表型检测。在金黄色葡萄球菌中，组成型大环内酯耐药表型占主导（60%），其次是诱导型（35%）和克林霉素敏感型（5%）表型。在CoNS中，诱导型表型比组成型表型更常见（50%对41%）。诱导型克林霉素耐药的发生率较高，有必要对所有葡萄球菌进行筛查，以便将诱导型耐药分离株与真正敏感的分离株区分开来。
