Azap O K, Arslan H, Timurkaynak F, Yapar G, Oruç E, Gagir U
Baskent University Faculty of Medicine, Infectious Disease and Clinical Microbiology, Ankara, Turkey.
Clin Microbiol Infect. 2005 Jul;11(7):582-4. doi: 10.1111/j.1469-0691.2005.01174.x.
In total, 408 staphylococcal isolates were tested for inducible clindamycin resistance (ICR) by the disk-diffusion induction test (D-test). ICR was detected in 5.7% of 105 methicillin-resistant Staphylococcus aureus (MRSA) isolates, 3.6% of 111 methicillin-susceptible S. aureus isolates, 30.8% of 94 methicillin-resistant coagulase-negative staphylococcal (CoNS) isolates, and 11.2% of 98 methicillin-sensitive CoNS isolates. All MRSA isolates that were erythromycin-resistant and clindamycin-susceptible were positive by the D-test. The same results were obtained with an azithromycin instead of an erythromycin disk. All isolates were susceptible to quinupristin-dalfopristin. The cost-benefit of the d-test should be evaluated locally after determining the incidence of the different resistance phenotypes.
总共对408株葡萄球菌分离株进行了纸片扩散诱导试验（D试验）以检测诱导型克林霉素耐药性（ICR）。在105株耐甲氧西林金黄色葡萄球菌（MRSA）分离株中，5.7%检测到ICR；在111株甲氧西林敏感金黄色葡萄球菌分离株中，3.6%检测到ICR；在94株耐甲氧西林凝固酶阴性葡萄球菌（CoNS）分离株中，30.8%检测到ICR；在98株甲氧西林敏感CoNS分离株中，11.2%检测到ICR。所有对红霉素耐药且对克林霉素敏感的MRSA分离株D试验均为阳性。用阿奇霉素纸片代替红霉素纸片也得到相同结果。所有分离株对奎奴普丁-达福普汀均敏感。在确定不同耐药表型的发生率后，应在当地评估D试验的成本效益。
