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瑞典幼儿家庭散发性弯曲杆菌病的危险因素

Risk factors for domestic sporadic campylobacteriosis among young children in Sweden.

作者信息

Carrique-Mas Juan, Andersson Yvonne, Hjertqvist Marika, Svensson Ake, Torner Anna, Giesecke Johan

机构信息

Department of Epidemiology of Infectious Diseases, Swedish Institute for Infectious Disease Control, Nobels väg, Solna, Sweden.

出版信息

Scand J Infect Dis. 2005;37(2):101-10. doi: 10.1080/00365540510027165.

Abstract

A case-control study was conducted in Sweden to study risk factors for domestically acquired Campylobacter jejuni/coli infections among children aged less than 6 y. A total of 126 cases, reported to the national surveillance system were recruited over 1 y. Controls, selected from the population register, were matched to the cases by age, gender, place of residence and time of infection of the case. Information was gathered by posted questionnaires. Two separate conditional regression models were developed including and excluding 'protective' factors. Two of the factors significantly associated with Campylobacter infection were water-related: having a well in the household (OR=2.6) and drinking water from a lake/river (OR=7.4; 6.0). Other exposures associated with increased risk were: having a dog (OR=8.4; 3.8) and eating grilled meat (OR=5.5; 2.1). Drinking unpasteurized milk was borderline significant in 1 model (OR=3.7). Eating sausage was protective (OR=0.05). Eating chicken was not a significant risk. Exposures such as eating grilled meat and drinking water from a lake or a river were more common in the warm months, a factor that may partly explain the observed seasonality. The authors suggest that differences between risk factors across studies may reflect geographical and age-specific differences in the sources of infection.

摘要

在瑞典开展了一项病例对照研究,以探究6岁以下儿童国内获得性空肠弯曲菌/结肠弯曲菌感染的风险因素。在1年多的时间里,共招募了126例向国家监测系统报告的病例。从人口登记册中选取对照,按照病例的年龄、性别、居住地点和感染时间进行匹配。通过邮寄问卷收集信息。建立了两个单独的条件回归模型,一个包含“保护”因素,另一个不包含。与弯曲菌感染显著相关的两个因素与水有关:家中有井(比值比=2.6)以及饮用湖水/河水(比值比=7.4;6.0)。其他与风险增加相关的暴露因素有:养狗(比值比=8.4;3.8)和食用烤肉(比值比=5.5;2.1)。饮用未经巴氏杀菌的牛奶在1个模型中接近显著(比值比=3.7)。食用香肠具有保护作用(比值比=0.05)。食用鸡肉不是显著的风险因素。诸如食用烤肉和饮用湖水或河水等暴露因素在温暖月份更为常见,这一因素可能部分解释了观察到的季节性。作者认为,不同研究中风险因素的差异可能反映了感染源在地理和特定年龄方面的差异。

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