Lorsheyd A, de Lange D W, Hijmering M L, Cramer M J M, van de Wiel A
Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands.
Neth J Med. 2005 Feb;63(2):59-63.
Acute, excessive alcohol intake has been associated with an increased cardiovascular mortality in otherwise healthy individuals. It predisposes to accelerated atherosclerosis resulting in acute coronary events but also arrhythmias have been described, such as atrial fibrillation and life-threatening re-entrant ventricular arrhythmias. QTc prolongation is associated with an increased risk of ventricular tachyarrhythmias and an independent risk factor for sudden cardiac death. The aim of the study is to investigate the effect of binge drinking on the conduction intervals in healthy individuals.
Ten of the volunteers drank red wine while the other ten volunteers drank a sweet designer drink. A follow-up of blood pressure, heart rate, ECG and laboratory findings was performed at an ethanol level of 0, 0.4 and 0.8%, respectively.
Fifteen volunteers showed a prolongation of the PR interval, 13 of the QRS complex, 9 of the QT interval and 13 of the QTc interval. PR interval increased from 149 +/- 16 ms to 163 +/- 11 ms (p < 0.05). The heart rate-adjusted QT interval increased from 400 +/- 24 ms to 426 +/- 52 ms (p < 0.05). Heart rate and systolic blood pressure did not significantly change due to the ingestion.
Acute ingestion of alcohol in a healthy population can induce prolongation of PR and QTc interval.
急性过量饮酒与原本健康个体的心血管死亡率增加有关。它易导致动脉粥样硬化加速，引发急性冠状动脉事件，同时也有关于心律失常的描述，如心房颤动和危及生命的折返性室性心律失常。QTc延长与室性快速心律失常风险增加相关，是心源性猝死的独立危险因素。本研究的目的是调查暴饮对健康个体传导间期的影响。
10名志愿者饮用红酒，另外10名志愿者饮用一种特制甜味饮料。分别在乙醇浓度为0%、0.4%和0.8%时对血压、心率、心电图和实验室检查结果进行随访。
15名志愿者PR间期延长，13名QRS波群延长，9名QT间期延长，13名QTc间期延长。PR间期从149±16毫秒增至163±11毫秒（p<0.05）。心率校正后的QT间期从400±24毫秒增至426±52毫秒（p<0.05）。摄入酒精后心率和收缩压无显著变化。
健康人群急性摄入酒精可导致PR和QTc间期延长。
