Lynn A K, Bonfield W
Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge CB2 1TP, United Kingdom.
Acc Chem Res. 2005 Mar;38(3):202-7. doi: 10.1021/ar040234d.
Calcium phosphate (CaP) bioceramics have long been of interest for the unique properties that they exhibit as bone substitute materials. By harnessing the unique bone-bonding capacity of CaP's, biomaterials scientists have made great strides over the past 2 decades to produce novel materials to assist in the treatments of defects caused by trauma, disease, or both. In recent years, however, it has become apparent that the traditional set of techniques used to produce calcium phosphates does not satisfy all of the requirements necessary to meet the challenges of emerging applications. In particular, recent interest in (i) the synthesis of coprecipitated CaP/bioorganic composites and (ii) the investigation of the mechanisms of biomineralization has highlighted the need for new methods to control pH and CaP mass yield.
磷酸钙（CaP）生物陶瓷长期以来一直备受关注，因为它们作为骨替代材料具有独特的性能。通过利用CaP独特的骨结合能力，生物材料科学家在过去20年里取得了巨大进展，生产出新型材料以协助治疗由创伤、疾病或两者引起的缺损。然而，近年来，很明显用于生产磷酸钙的传统技术组不能满足应对新兴应用挑战所需的所有要求。特别是，最近对（i）共沉淀CaP/生物有机复合材料的合成和（ii）生物矿化机制的研究突出了对控制pH值和CaP质量产率的新方法的需求。
