Department of Chemistry G. Ciamician, University of Bologna, 40126 Bologna, Italy.
Acta Biomater. 2010 Jun;6(6):1882-94. doi: 10.1016/j.actbio.2009.12.041. Epub 2009 Dec 28.
Ionic substitutions have been proposed as a tool to improve the biological performance of calcium phosphate based materials. This review provides an overview of the recent results achieved on ion-substituted calcium phosphates prepared at low temperature, i.e. by direct synthesis in aqueous medium or through hydrolysis of more soluble calcium phosphates. Particular attention is focused on several ions, including Si, Sr, Mg, Zn and Mn, which are attracting increasing interest for their possible biological role, and on the recent trends and developments in the applications of ion-substituted calcium phosphates in the biomedical field.
离子取代被提议作为一种改善基于磷酸钙的材料的生物性能的工具。本综述概述了在低温下制备的离子取代的磷酸钙的最新研究结果，即通过在水溶液中直接合成或通过更易溶的磷酸钙的水解来制备。特别关注几种离子，包括 Si、Sr、Mg、Zn 和 Mn，它们因其可能的生物学作用而引起越来越多的关注，以及离子取代的磷酸钙在生物医学领域的应用的最新趋势和发展。
