Tung Ko-Hui, Wilkens Lynne R, Wu Anna H, McDuffie Katharine, Hankin Jean H, Nomura Abraham M Y, Kolonel Laurence N, Goodman Marc T
Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA.
Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):669-76. doi: 10.1158/1055-9965.EPI-04-0550.
Antioxidants may protect the ovaries from oxidative damage and reduce the risk of ovarian cancer. Although a few studies have examined the relation of antioxidant intake to the risk of ovarian cancer, the results have been inconclusive. Questions still remain regarding the effects of confounding factors, such as menopause, tobacco smoking, and alcohol drinking, on the association between antioxidants and ovarian cancer development.
To examine the association of the consumption of micronutrients from foods and supplements with the risk of ovarian cancer.
A structured questionnaire was administered to 558 histologically confirmed epithelial ovarian cancer cases and 607 population controls from a multiethnic, population-based case-control study conducted between 1993 and 1999 in Hawaii and Los Angeles.
Overall, vitamin A and carotene intakes were modestly associated with a reduced risk of ovarian cancer. Inverse gradients in ovarian cancer risk with increasing dietary intake of vitamin A and beta-carotene were somewhat stronger among women with mucinous histologic types, smokers, and nondrinkers. A significant positive trend in risk associated with increasing beta-cryptoxanthin intake was observed among postmenopausal women, among women with nonmucinous tumors, and among nonsmokers. The intake of other carotenoids and antioxidants, either from foods or supplements, was unrelated to ovarian cancer risk.
Our findings suggest that dietary vitamin A and beta-carotene are modestly protective against ovarian cancer, particularly among smokers. Our data suggest a role for retinoic acid signaling pathways in ovarian carcinogenesis.
抗氧化剂可能保护卵巢免受氧化损伤并降低卵巢癌风险。尽管有一些研究探讨了抗氧化剂摄入量与卵巢癌风险之间的关系，但结果尚无定论。关于诸如绝经、吸烟和饮酒等混杂因素对抗氧化剂与卵巢癌发生之间关联的影响，仍存在疑问。
研究从食物和补充剂中摄入微量营养素与卵巢癌风险之间的关联。
对1993年至1999年在夏威夷和洛杉矶进行的一项基于人群的多民族病例对照研究中的558例经组织学确诊的上皮性卵巢癌病例和607名人群对照进行了结构化问卷调查。
总体而言，维生素A和胡萝卜素摄入量与卵巢癌风险降低适度相关。在黏液性组织学类型的女性、吸烟者和不饮酒者中，随着维生素A和β-胡萝卜素膳食摄入量增加，卵巢癌风险的反向梯度更强。在绝经后女性、非黏液性肿瘤女性和非吸烟者中，观察到随着β-隐黄质摄入量增加，风险呈显著正趋势。从食物或补充剂中摄入的其他类胡萝卜素和抗氧化剂与卵巢癌风险无关。
我们的研究结果表明，膳食中的维生素A和β-胡萝卜素对卵巢癌有适度的保护作用，尤其是在吸烟者中。我们的数据表明视黄酸信号通路在卵巢癌发生中起作用。
