Thomson Cynthia A, Neuhouser Marian L, Shikany James M, Caan Bette J, Monk Bradley J, Mossavar-Rahmani Yasmin, Sarto Gloria, Parker Linda M, Modugno Francesmary, Anderson Garnet L
Department of Nutritional Sciences and Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA.
Nutr Cancer. 2008;60(6):710-9. doi: 10.1080/01635580802233983.
Antioxidant nutrients and carotenoids have been inconsistently associated with ovarian cancer risk. We examined the relationship between intake of dietary and supplemental antioxidant nutrients including vitamins C, E, and selenium as well as carotenoids and vitamin A and ovarian cancer in 133,614 postmenopausal women enrolled in the Women's Health Initiative (WHI) study. Dietary intake was assessed using a food frequency questionnaire, and ovarian cancer endpoints were centrally adjudicated. Cox regression models were used to estimate the risk for invasive ovarian cancer in relation to each of the antioxidant nutrients and carotenoids under consideration using models stratified for a WHI study component. A total of 451 cases of invasive ovarian cancer were diagnosed over 8.3 yr of follow-up. Dietary intake at baseline was not significantly different for cases vs. controls. Cases reported greater intake of supplemental vitamin C (358.0 mg/day vs. 291.6 mg/day, respectively; P = 0.024). Multivariate modeling (P for trend) of the risk for developing ovarian cancer did not suggest any significant relationships among dietary factors and ovarian cancer risk. The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk.
抗氧化营养素和类胡萝卜素与卵巢癌风险之间的关联并不一致。我们在参加女性健康倡议（WHI）研究的133,614名绝经后女性中，研究了膳食和补充抗氧化营养素（包括维生素C、E和硒）以及类胡萝卜素和维生素A的摄入量与卵巢癌之间的关系。使用食物频率问卷评估膳食摄入量，并由中心对卵巢癌终点进行判定。使用Cox回归模型，在根据WHI研究组成部分分层的模型中估计每种所考虑的抗氧化营养素和类胡萝卜素与侵袭性卵巢癌风险的关系。在8.3年的随访期间共诊断出451例侵袭性卵巢癌病例。病例组和对照组的基线膳食摄入量无显著差异。病例组报告的补充维生素C摄入量更高（分别为358.0毫克/天和291.6毫克/天；P = 0.024）。对患卵巢癌风险的多变量建模（趋势P值）未显示膳食因素与卵巢癌风险之间存在任何显著关系。这项针对营养良好的绝经后女性的前瞻性研究结果表明，膳食抗氧化剂、类胡萝卜素和维生素A的摄入量与卵巢癌风险降低无关。
