Graduate School, Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Gansu Provincial Hospital, Lanzhou, Gansu 730000, China.
Oxid Med Cell Longev. 2022 Nov 2;2022:7686405. doi: 10.1155/2022/7686405. eCollection 2022.
According to relevant clinical research, dietary and circulating antioxidants vitamin A are connected with the risk of breast, cervical, and ovarian cancer in women. However, there was inconsistency between the findings. We completed this meta-analysis at the right moment to address this contradiction of the problem.
Web of Science, Embase, and PubMed databases were searched using the proposed search strategy and filtered using the inclusion and exclusion criteria as well as the NOS quality score. As of May 2022, low intake or low concentration was used as a control, and odds ratio (OR) or relative risk (RR) and ninety-five percent confidence intervals (95% CI) were extracted for high intake. Stata 12.0 was used to process the data.
Our meta-analysis included a total of 49 studies, 29 on breast cancer, 10 on ovarian cancer, and 10 on cervical cancer. There were 38 case-control studies included, with 25,363 cases and 42,281 controls; there were 11 cohort studies included, 1,334,176 individuals were followed up, and finally 9496 obtained cancer. The pooled OR value results were as follows: diet or supplements (OR = 0.83, 95% CI 0.76-0.90, = 56.1%) and serum or plasma (OR = 0.96, 95% CI 0.86-1.09, = 29.5%). Subgroup analyses were performed according to cancer type, diet or supplements, serum or plasma, study type, and geographic regions.
In North American and Asian populations, high dietary consumption of vitamin A or supplements decreases the incidence of three cancers in women, with breast and ovarian cancers being more significant. However, high circulating vitamin A concentrations were not significantly connected with the risk of the three malignancies.
根据相关临床研究，饮食和循环中的抗氧化剂维生素 A 与女性患乳腺癌、宫颈癌和卵巢癌的风险有关。然而，研究结果并不一致。我们在适当的时候完成了这项荟萃分析，以解决这个问题的矛盾。
使用提出的搜索策略搜索 Web of Science、Embase 和 PubMed 数据库，并使用纳入和排除标准以及 NOS 质量评分进行过滤。截至 2022 年 5 月，低摄入量或低浓度作为对照，提取高摄入量的比值比（OR）或相对风险（RR）和 95%置信区间（95%CI）。使用 Stata 12.0 处理数据。
我们的荟萃分析共纳入 49 项研究，其中 29 项关于乳腺癌，10 项关于卵巢癌，10 项关于宫颈癌。共纳入 38 项病例对照研究，病例 25363 例，对照 42281 例；纳入 11 项队列研究，共随访 1334176 人，最终 9496 人发生癌症。汇总 OR 值结果如下：饮食或补充剂（OR=0.83，95%CI 0.76-0.90， = 56.1%）和血清或血浆（OR=0.96，95%CI 0.86-1.09， = 29.5%）。根据癌症类型、饮食或补充剂、血清或血浆、研究类型和地理位置进行亚组分析。
在北美和亚洲人群中，高维生素 A 饮食或补充剂的摄入降低了女性三种癌症的发病率，乳腺癌和卵巢癌更为显著。然而，高循环维生素 A 浓度与三种恶性肿瘤的风险无显著相关性。
