Maevsky Eugene, Ivanitsky Genrih, Bogdanova Ludmila, Axenova Olga, Karmen Natalia, Zhiburt Eugene, Senina Raisa, Pushkin Sergey, Maslennikov Igor, Orlov Andrey, Marinicheva Irina
Institute of Theoretical and Experimental Biophysics of RAS, Moscow Region, Russia.
Artif Cells Blood Substit Immobil Biotechnol. 2005;33(1):37-46. doi: 10.1081/bio-200046654.
Clinical experience of Perftoran (commercial drug of low concentrated perfluorocheminal emulsion) applications is presented in some statistical data and in brief analysis of clinical trials and following clinical studies described in the Russian scientific literature. Observed data allow us to suppose that Perftoran facilitates oxygen delivery together with remaining red blood cells at blood replacements and will have more wider area for application than just a blood substitute. Its infusion alleviates symptoms of ischemia at different types of occlusion vessels disease, improves grafting in plastic surgery, diminishes inflammation and prevents rejection of transplants, activates detoxication functions of liver, inhibits retro-virus infection development. Local PF applications is able to accelerate wounds and ulcers healing.
本文依据俄罗斯科学文献中描述的一些统计数据、临床试验简要分析及后续临床研究，介绍了全氟托兰（低浓度全氟化学乳剂的商品名）的临床应用经验。观察数据使我们推测，在输血时全氟托兰能与剩余红细胞共同促进氧气输送，其应用范围将比单纯的血液替代品更广泛。输注全氟托兰可缓解不同类型血管闭塞性疾病的缺血症状，改善整形手术中的移植效果，减轻炎症并防止移植排斥反应，激活肝脏的解毒功能，抑制逆转录病毒感染的发展。局部应用全氟托兰能够加速伤口和溃疡的愈合。
