Ertl Georg, Frantz Stefan
Medizinische Universitätsklinik Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Cardiovasc Res. 2005 Apr 1;66(1):22-32. doi: 10.1016/j.cardiores.2005.01.011.
Wounding and healing are archaic principles, prerequisite for survival of any biologic material. However, strategies to cope with wounding may be quite different among organisms, species, or among various organs of one species. Today, myocardial infarction and the consequent loss of fully functional myocardium is the major aetiology for heart failure. Despite aggressive primary therapy, prognosis remains serious in patients with large infarction and severe left ventricular dysfunction. Thus, it would be highly desirable to influence healing of the cardiac wound to maintain structure and function of the heart. Herein, we review different, important factors of cardiac healing including reperfusion, mechanical stress, gender, and neurohormonal factors as well as specific factors essential for healing which may be genetic or acquired, emphasizing similarities and discrepancies between different organs and species.
创伤与愈合是古老的原则，是任何生物物质生存的先决条件。然而，生物体之间、物种之间或同一物种的不同器官之间应对创伤的策略可能大不相同。如今，心肌梗死以及随之而来的完全功能性心肌丧失是心力衰竭的主要病因。尽管进行了积极的初级治疗，但大面积梗死和严重左心室功能障碍患者的预后仍然严峻。因此，非常希望能够影响心脏创伤的愈合，以维持心脏的结构和功能。在此，我们综述心脏愈合的不同重要因素，包括再灌注、机械应力、性别和神经激素因素，以及愈合所必需的特定因素，这些因素可能是遗传的或后天获得的，强调不同器官和物种之间的异同。
