Genetics. Was the Human Genome Project worth the effort?
作者信息
Daiger Stephen P
机构信息
Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77030, USA.
出版信息
Science. 2005 Apr 15;308(5720):362-4. doi: 10.1126/science.1111655. Epub 2005 Mar 15.
Abstract
摘要
相似文献
1
Genetics. Was the Human Genome Project worth the effort?遗传学。人类基因组计划值得付出努力吗？
Science. 2005 Apr 15;308(5720):362-4. doi: 10.1126/science.1111655. Epub 2005 Mar 15.
2
Complement factor H polymorphism in age-related macular degeneration.年龄相关性黄斑变性中的补体因子H多态性
Science. 2005 Apr 15;308(5720):385-9. doi: 10.1126/science.1109557. Epub 2005 Mar 10.
3
Complement factor H polymorphism and age-related macular degeneration.补体因子H基因多态性与年龄相关性黄斑变性
Science. 2005 Apr 15;308(5720):421-4. doi: 10.1126/science.1110189. Epub 2005 Mar 10.
4
Complement factor H variant increases the risk of age-related macular degeneration.补体因子H变异体增加年龄相关性黄斑变性的风险。
Science. 2005 Apr 15;308(5720):419-21. doi: 10.1126/science.1110359. Epub 2005 Mar 10.
5
Age-related macular degeneration genetics.年龄相关性黄斑变性遗传学
Ophthalmology. 2008 May;115(5):916-916.e1. doi: 10.1016/j.ophtha.2007.12.012.
6
Ethnic variation in AMD-associated complement factor H polymorphism p.Tyr402His.年龄相关性黄斑变性（AMD）相关补体因子H基因多态性p.Tyr402His的种族差异
Hum Mutat. 2006 Sep;27(9):921-5. doi: 10.1002/humu.20359.
7
Role of genetic factors and inflammation in age-related macular degeneration.遗传因素与炎症在年龄相关性黄斑变性中的作用。
Retina. 2007 Mar;27(3):269-75. doi: 10.1097/IAE.0b013e31802e3e9b.
8
Genetics of age-related macular degeneration.
Adv Exp Med Biol. 2008;613:211-9. doi: 10.1007/978-0-387-74904-4_24.
9
Almost total protection from age-related macular degeneration by haplotypes of the Regulators of Complement Activation.补体激活调节剂单倍型对年龄相关性黄斑变性的近乎完全保护作用。
Genomics. 2011 Dec;98(6):412-21. doi: 10.1016/j.ygeno.2011.08.002. Epub 2011 Aug 9.
10
Genetics. A clearer view of macular degeneration.
Science. 2006 Mar 24;311(5768):1704-5. doi: 10.1126/science.311.5768.1704.
引用本文的文献
1
Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives.表观遗传学在牙周学领域的最新进展：ENCODE 项目的回顾与未来展望。
Clin Epigenetics. 2021 Apr 26;13(1):92. doi: 10.1186/s13148-021-01074-w.
2
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics.补体系统的治疗靶向：从罕见病到流行病。
Pharmacol Rev. 2021 Apr;73(2):792-827. doi: 10.1124/pharmrev.120.000072.
3
Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material.高度分化的人胎儿 RPE 培养物对脂褐素样物质的积累和毒性具有抗性。
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3468-3479. doi: 10.1167/iovs.19-26690.
4
2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation.2018 年兰利奖基础尼古丁与烟草研究奖：将精准医学应用于戒烟。
Nicotine Tob Res. 2020 Feb 6;22(2):147-151. doi: 10.1093/ntr/ntz036.
5
A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy.随后将人类神经祖细胞移植到退化的视网膜中不会损害初始移植物的存活或治疗效果。
Transl Vis Sci Technol. 2015 Feb 10;4(1):7. doi: 10.1167/tvst.4.1.7. eCollection 2015 Feb.
6
Subretinal infiltration of monocyte derived cells and complement misregulation in mice with AMD-like pathology.AMD 样病变小鼠中单核细胞衍生细胞的视网膜下浸润和补体失调。
Adv Exp Med Biol. 2014;801:355-63. doi: 10.1007/978-1-4614-3209-8_45.
7
Public-private partnership as a solution for integrating genetic services into health care of countries with low and middle incomes.公私伙伴关系是将基因服务纳入低收入和中等收入国家卫生保健体系的一种解决方案。
J Community Genet. 2013 Jul;4(3):309-20. doi: 10.1007/s12687-012-0099-8. Epub 2012 May 22.
8
Identification of a central role for complement in osteoarthritis.鉴定补体在骨关节炎中的核心作用。
Nat Med. 2011 Nov 6;17(12):1674-9. doi: 10.1038/nm.2543.
9
Detecting Genes and Gene-gene Interactions for Age-related Macular Degeneration with a Forest-based Approach.基于随机森林方法检测年龄相关性黄斑变性的基因及基因-基因相互作用
Stat Biopharm Res. 2009 Nov 1;1(4):424-430. doi: 10.1198/sbr.2009.0046.
10
Maximal conditional chi-square importance in random forests.随机森林中的最大条件卡方重要性。
Bioinformatics. 2010 Mar 15;26(6):831-7. doi: 10.1093/bioinformatics/btq038. Epub 2010 Feb 3.
本文引用的文献
1
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions.年龄相关性黄斑病变：一项全基因组扫描，持续证明1q31、10q26和17q25区域内存在易感基因座。
Am J Hum Genet. 2004 Aug;75(2):174-89. doi: 10.1086/422476. Epub 2004 May 27.
2
Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease.年龄相关性黄斑变性：对晚期疾病富集人群中易感性位点进行的高分辨率基因组扫描。
Am J Hum Genet. 2004 Mar;74(3):482-94. doi: 10.1086/382786. Epub 2004 Feb 16.
3
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration.对大家庭全基因组扫描数据的剖析揭示了年龄相关性黄斑变性的一个主要基因座和寡基因易感性。
Am J Hum Genet. 2004 Jan;74(1):20-39. doi: 10.1086/380912. Epub 2003 Dec 19.
4
The International HapMap Project.国际人类基因组单体型图计划
Nature. 2003 Dec 18;426(6968):789-96. doi: 10.1038/nature02168.
5
A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions.一项针对年龄相关性黄斑变性的全基因组扫描为与多个染色体区域的连锁提供了证据。
Am J Hum Genet. 2003 Oct;73(4):780-90. doi: 10.1086/378505. Epub 2003 Aug 22.
6
Dependence of mutational asymmetry on gene-expression levels in the human genome.人类基因组中突变不对称性对基因表达水平的依赖性。
Am J Hum Genet. 2003 Sep;73(3):688-92. doi: 10.1086/378134. Epub 2003 Jul 24.
7
Risk factors for age-related macular degeneration: an update.年龄相关性黄斑变性的危险因素：最新进展
Curr Opin Ophthalmol. 2002 Jun;13(3):171-5. doi: 10.1097/00055735-200206000-00007.
8
Molecular genetics of age-related macular degeneration.
Hum Mol Genet. 2001 Oct 1;10(20):2285-92. doi: 10.1093/hmg/10.20.2285.
9
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration.一种综合假说，该假说认为玻璃膜疣是衰老和年龄相关性黄斑变性中视网膜色素上皮- Bruch膜界面免疫介导过程的生物标志物。
Prog Retin Eye Res. 2001 Nov;20(6):705-32. doi: 10.1016/s1350-9462(01)00010-6.
10
An analysis of allelic variation in the ABCA4 gene.ABCA4基因的等位基因变异分析。
Invest Ophthalmol Vis Sci. 2001 May;42(6):1179-89.
Zotero 插件