Ozekmekçi Sibel, Kiziltan Günes, Vural Melih, Ertan Sibel, Apaydin Hülya, Erginöz Ethem
Dept. of Neurology, Medical School of Cerrahpasa Istanbul University, 34098 Istanbul, Turkey.
J Neurol. 2005 Aug;252(8):964-7. doi: 10.1007/s00415-005-0793-0. Epub 2005 Mar 21.
We have observed mild bradykinesia in essential tremor (ET) patients, which do not satisfy the criteria of Parkinson's disease (PD).
To compare the mean movement time for repetitive movements around distal and proximal joints in ET patients with normal controls by using a simple test paradigm.
Seventeen patients with ET and 14 control subjects were instructed to tap with the index finger sequentially on push-button microswitches. Movement times around metacarpophalangeal, wrist, elbow, and shoulder joints of the right side were tested. The data collected were stored on a computer and the time elapsed between sequential taps on two keys (ms) and number of taps on the left key for 15 seconds were evaluated offline.
Movement times of the patients with ET were not found to be significantly different from those of the controls at all joints tested despite slight prolongation for movements around the shoulder joint.
The simple test paradigm we have used showed that there is no difference in the movement time for repetitive movements around four joints of the upper extremity between patients with ET and normal control subjects. The slightly prolonged movement time around the shoulder joint noted in patients with ET may be ascribed to tremor, not bradykinesia. Tremor may cause these patients to pay more attention to the performance of goal-directed finger movements and consequently prolong movement time slightly or it may simply delay the time elapsed to reach the goal in the absence of overt intention tremor.
我们观察到原发性震颤（ET）患者存在轻度运动迟缓，但这些患者不符合帕金森病（PD）的诊断标准。
通过使用一种简单的测试范式，比较ET患者与正常对照者在远端和近端关节周围进行重复性运动的平均运动时间。
指导17例ET患者和14名对照者用食指依次轻敲按钮式微动开关。测试右侧掌指关节、腕关节、肘关节和肩关节周围的运动时间。收集的数据存储在计算机上，并离线评估两个按键依次轻敲之间的时间间隔（毫秒）以及15秒内左键的轻敲次数。
尽管ET患者肩关节周围的运动时间略有延长，但在所有测试关节中，ET患者的运动时间与对照组相比无显著差异。
我们使用的简单测试范式表明，ET患者与正常对照者在上肢四个关节周围进行重复性运动的运动时间没有差异。ET患者肩关节周围运动时间略有延长可能归因于震颤，而非运动迟缓。震颤可能导致这些患者更加关注目标导向的手指运动表现，从而使运动时间略有延长，或者在没有明显意向性震颤的情况下，它可能只是延迟了达到目标的时间。
