Murina Filippo, Radici Gianluigi, Bianco Vanda
Outpatients' Department of Vulvar Disease, Vittore Buzzi Hospital-ICP-First, Obstetrics and Gynecological Clinic, University of Milan, Milan, Italy.
MedGenMed. 2004 Dec 8;6(4):48.
To assess the efficacy of topical capsaicin in the treatment of vulvar vestibulitis syndrome.
Thirty-three consecutive women referred for vulvar vestibulitis syndrome were treated with topical capsaicin 0.05 %. The capsaicin cream was applied twice a day for 30 days, then once a Day for 30 days, and finally 2 times a week for 4 months.
In 19 patients (59%), improvement of symptoms was recorded, but no complete remission was observed. Symptoms recurred in all patients after the use of capsaicin cream was discontinued. A return to a twice-weekly topical application of the cream resulted in the improvement of symptoms. Severe burning was reported as the only side effect by all the patients.
Response to treatment was only partial, possibly due to the concentration of the compound being too low, or to the need for more frequent than daily applications. The therapeutic role of capsaicin should hence be confined to a last-choice medical approach.
评估外用辣椒素治疗外阴前庭炎综合征的疗效。
连续33例因外阴前庭炎综合征转诊的女性接受0.05%的外用辣椒素治疗。辣椒素乳膏每天涂抹两次，持续30天，然后每天涂抹一次，持续30天，最后每周涂抹两次，持续4个月。
19例患者（59%）症状有所改善，但未观察到完全缓解。停用辣椒素乳膏后，所有患者症状均复发。恢复每周两次外用该乳膏可使症状改善。所有患者均报告严重灼痛为唯一副作用。
治疗反应仅为部分有效，可能是由于该化合物浓度过低，或因需要比每日应用更频繁地用药。因此，辣椒素的治疗作用应限于作为最后的药物治疗方法。
