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[超声引导下透明质酸钠凝胶(Hylan G-F 20)关节腔内注射治疗髋骨关节炎。随访12个月后的临床结果]

[Intra-articular treatment with Hylan G-F 20 under ultrasound guidance in hip osteoarthritis. Clinical results after 12 months follow-up].

作者信息

Migliore A, Tormenta S, Valente C, Massafra U, Martin Martin L S, Carmenini E, Bernardini A, Alimonti A

机构信息

Dipartimento di Medicina Interna, Ospedale S.Pietro-Fatebenefratelli, Via Cassia, 600-00192 Rome.

出版信息

Reumatismo. 2005 Jan-Mar;57(1):36-43. doi: 10.4081/reumatismo.2005.36.

Abstract

Hip is a site very commonly affected by osteoarthritis (OA), yet few data exist in literature regarding intra-articular use of hyaluronic acid in this pathology. We evaluated the efficacy of Hylan G-F 20 hip viscosupplementation performed under ultrasound guidance. We enrolled 26 patients affected by symptomatic hip OA and treated them with a single intraarticular injection of Hylan G-F 20, which could be repeated every two months. The injection was performed under ultrasound guidance with an antero-superior approach. Treatment efficacy was assessed through Lequesne index, visual analogue scale (VAS) pain quantification, and NSAID intake at the timepoint zero (baseline), and after 2, 6 and 12 months. We observed a statistically significant reduction of all considered parameters at the timepoints 2 and 6 months, when compared to baseline. At 12 months the changes were still statistically significant for all parameters for about 50% of the patients. No side effect was observed, nor systemic complication. Viscosupplementation is a promising approach for hip OA, although further and wider studies are wanted to determine how long the beneficial effect lasts, and what is the optimal number of injections to administer.

摘要

髋关节是骨关节炎(OA)非常常见的受累部位,但关于透明质酸在这种病理情况下关节内使用的文献资料很少。我们评估了在超声引导下进行的Hylan G-F 20髋关节粘弹性补充疗法的疗效。我们纳入了26例有症状的髋关节OA患者,并对他们进行了单次关节内注射Hylan G-F 20治疗,每两个月可重复注射一次。注射采用前上方入路在超声引导下进行。通过Lequesne指数、视觉模拟量表(VAS)疼痛量化以及在第0时间点(基线)、2个月、6个月和12个月时的非甾体抗炎药摄入量来评估治疗效果。与基线相比,我们观察到在第2个月和第6个月时所有考虑的参数均有统计学意义的降低。在12个月时,约50%的患者所有参数的变化仍具有统计学意义。未观察到副作用或全身并发症。粘弹性补充疗法是治疗髋关节OA的一种有前景的方法,尽管需要进一步更广泛的研究来确定有益效果能持续多久以及最佳注射次数是多少。

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