Migliore Alberto, Tormenta Sandro, Massafra Umberto, Martin Martin Luis Severino, Carloni Emilia, Padalino Cristiano, Alimonti Andrea, Granata Mauro
U.O.S. di Reumatologia, S. Pietro-Fatebenefratelli Ospedale, 00189 Roma.
Reumatismo. 2006 Jan-Mar;58(1):39-49.
To evaluate the efficacy and the tolerability of viscosupplementation (VS) with hyaluronic acid (Hylan GF 20) in a cohort of 36 patients affected by hip osteoarthritis through a 18 months follow-up.
Viscosupplementation was performed with an anteriorsagittal approach, under ultrasound guidance. 36 patients were administered hyaluronic acid intraarticularly in the hip, with a unique injection of Hylan G-F20, which could be repeated after at least 3 months. Treatment efficacy was assessed by functional index WOMAC, pain evaluation on a visual analogue scale and NSAID consumption. All such parameters were recorded at the time of the first injection and then 3, 6, 9, 12 and 18 months later.
Statistically significant reduction of all parameters was observed three months after the injection, and was still maintained at the timepoints 6, 9, 12 and 18 months. No local side effects have been observed, nor systemic complications.
Our data show that viscosupplementation is a promising approach for hip osteoarthritis, providing beneficial effects in a long-term follow up. Yet, the topic deserves further and wider studies, so to define the number of injections to administer and suggest a fit interval between subsequent injections.
通过18个月的随访，评估透明质酸（Hylan GF 20）关节腔内注射补充疗法（VS）对36例髋骨关节炎患者的疗效和耐受性。
在超声引导下，采用前矢状入路进行关节腔内注射补充疗法。36例患者在髋关节内注射透明质酸，单次注射Hylan G-F20，至少3个月后可重复注射。通过WOMAC功能指数、视觉模拟量表疼痛评估和非甾体抗炎药消耗量评估治疗效果。所有这些参数在首次注射时记录，然后在3、6、9、12和18个月后记录。
注射后3个月观察到所有参数均有统计学意义的降低，在6、9、12和18个月时仍保持降低。未观察到局部副作用和全身并发症。
我们的数据表明，关节腔内注射补充疗法是治疗髋骨关节炎的一种有前景的方法，在长期随访中具有有益效果。然而，该主题值得进一步更广泛的研究，以确定注射次数并建议后续注射之间的合适间隔。
