Migliore A, Giovannangeli F, Granata M, Laganà B
UOS of Rheumatology, S.Pietro FBF Hospital, Rome, Italy.
Clin Med Insights Arthritis Musculoskelet Disord. 2010 Sep 20;3:55-68.
Osteoarthritis (OA) is a chronic degenerative joint disease that is a clinically and economically important disease. The increased prevalence of OA with aging, coupled to the demographics of aging populations, make OA a high priority health care problem. Viscosupplementation (VS) is a well-established treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, and could potentially provide a useful alternative in treating such patients with painful OA. Theoretically VS is an approach that should apply to all synovial joints.
The aim of this review is to assess the efficacy and safety of viscosupplementation with Hylan GF-20 (Synvisc(®)) in the management of joint pain in osteoarthritis.
THE FOLLOWING DATABASES WERE SEARCHED: Medline, Database of Abstract on Reviews and Effectiveness, Cochrane Database of Systematic Reviews. Furthermore, the lists of references of retrieved publications were manually checked for additional references. The search terms Review, Viscosupplementation, Osteoarthritis, Hyaluronic acid, Hyaluronan, Sodium Hyaluronate, Hylan GF-20, Synvisc, intra-articular injection were used to identify all studies relating to the use of Synvisc(®) viscosupplementation therapy in OA.
Hylan GF-20 is a safe and effective treatment for decreasing pain and improving function in patients suffering from knee and hip OA but new evidences are emerging for its use in other joints.
骨关节炎（OA）是一种慢性退行性关节疾病，在临床和经济方面都是重要疾病。OA的患病率随年龄增长而增加，再加上老龄化人口的统计数据，使得OA成为一个高度优先的医疗保健问题。关节腔注射透明质酸钠（VS）是膝关节OA中一种成熟的治疗选择，已被纳入该关节疾病的专业治疗指南，并且可能为治疗此类疼痛性OA患者提供一种有用的替代方法。理论上，VS是一种应适用于所有滑膜关节的方法。
本综述的目的是评估关节腔注射透明质酸钠（Hylan GF-20，商品名施沛特（Synvisc®））治疗骨关节炎关节疼痛的疗效和安全性。
检索了以下数据库：医学文献数据库、循证医学数据库、Cochrane系统评价数据库。此外，还手动检查了检索到的出版物的参考文献列表以获取其他参考文献。使用检索词“综述”“关节腔注射透明质酸钠”“骨关节炎”“透明质酸”“玻璃酸”“透明质酸钠”“Hylan GF-20”“施沛特”“关节内注射”来识别所有与施沛特（Synvisc®）关节腔注射补充疗法在OA中的应用相关的研究。
Hylan GF-20是一种安全有效的治疗方法，可减轻膝关节和髋关节OA患者的疼痛并改善其功能，但在其他关节使用的新证据也在不断涌现。
