Philip M A, Standen G, Fletcher J
Br J Haematol. 1980 Feb;44(2):263-8. doi: 10.1111/j.1365-2141.1980.tb01208.x.
Marked changes in the concentration and proliferative state of circulating granulocytic progenitor cells (colony forming units in culture; CFUc) were observed in female patients following surgical trauma. Within one day of an abdominal hysterectomy there was an abrupt fall in the number of blood CFUc to between 10% and 20% of normal and an increase in the proportion synthesizing DNA which coincided with the maximum neutrophilia. Subsequently, as the neutrophil count declined, the CFUc concentration increased to supranormal values and the proliferative response persisted, both parameters returning to normal 2 weeks after surgery. These results suggest that, following surgical trauma, the increased demand for neutrophils is rapidly met by increased CFUc proliferation.
在接受手术创伤的女性患者中，观察到循环粒细胞祖细胞（培养中的集落形成单位；CFUc）的浓度和增殖状态发生了显著变化。腹部子宫切除术后一天内，血液中CFUc的数量急剧下降至正常水平的10%至20%，同时合成DNA的比例增加，这与最大中性粒细胞增多同时出现。随后，随着中性粒细胞计数下降，CFUc浓度增加至超正常水平，增殖反应持续存在，两个参数在手术后2周恢复正常。这些结果表明，手术创伤后，对中性粒细胞的需求增加通过CFUc增殖增加而迅速得到满足。
