Kesebir Sermin, Vahip Simavi, Akdeniz Fisun, Yüncü Zeki, Alkan Müge, Akiskal Hagop
Affective Disorder Unit, Department of Psychiatry, Tip Fakultesi, Ege University, Bornova, Izmir 35100, Turkey.
J Affect Disord. 2005 Mar;85(1-2):127-33. doi: 10.1016/j.jad.2003.10.013.
The aims of this study were to identify the dominant affective temperamental characteristics of patients with bipolar disorder (BP) and their clinically well first-degree relatives and to compare the prevalence rates of these temperaments with those in healthy control subjects.
One hundred bipolar I probands and their 219 unaffected first-degree relatives were enrolled in the study. The control group consisted of healthy subjects without any personal or family history of bipolar disorder, matched with the age and gender of the probands and first-degree relatives. To identify the dominant affective temperaments, the Turkish version of TEMPS-A scale was used.
At least one dominant temperament was found in 26% of the proband group, in 21.9% of the relative group, and 6.0% and 10.0% of the control groups, respectively. The most noteworthy finding was that both the probands and their relatives had significantly higher frequency of hyperthymic temperament than the controls.
Temperament had not been assessed premorbidly in the probands with bipolar disorder.
The study supports the familial, possibly genetic, basis for the hyperthymic temperament in the genesis of bipolar I dosorder. That the cyclothymic temperament was not similarly represented, may be due to the higher specificity of the cyclothymic temperament to the bipolar II sybtype (which we did not study). More research is needed on the relevance of cyclothymic and other temperaments to the genetics of bipolar disorders selected by rigorous subtyping along the clinical spectrum of bipolarity.
本研究的目的是确定双相情感障碍（BP）患者及其临床状态良好的一级亲属的主要情感气质特征，并将这些气质的患病率与健康对照者进行比较。
本研究纳入了100名双相I型先证者及其219名未受影响的一级亲属。对照组由无双相情感障碍个人或家族史的健康受试者组成，其年龄和性别与先证者及一级亲属相匹配。为确定主要的情感气质，使用了TEMPS - A量表的土耳其语版本。
先证者组中26%、亲属组中21.9%以及对照组中分别有6.0%和10.0%的人至少有一种主要气质。最值得注意的发现是，先证者及其亲属的轻躁狂气质出现频率均显著高于对照组。
未对双相情感障碍先证者病前的气质进行评估。
本研究支持轻躁狂气质在双相I型障碍发病中的家族性（可能是遗传性）基础。环性气质未呈现类似情况，可能是由于环性气质对双相II型亚型（我们未研究）具有更高的特异性。需要对环性气质及其他气质与沿双相情感障碍临床谱系进行严格亚型分类所选择的双相情感障碍遗传学的相关性开展更多研究。
