Auguste Patrick, Lemiere Sylvie, Larrieu-Lahargue Fréderic, Bikfalvi Andreas
Molecular Angiogenesis Laboratory, Institut National de la Santé et de la Recherche Médicale (EMI 0113), Université de Bordeaux I, Talence, France.
Crit Rev Oncol Hematol. 2005 Apr;54(1):53-61. doi: 10.1016/j.critrevonc.2004.11.006.
Tumor angiogenesis is a fast growing sub-domain of angiogenesis research and tumor biology. Basic mechanisms have been unraveled and many key players identified. For many years, tumor vascularization was explained solely by the ingrowth of new vessels into the tumor from preexisting one's. However, in recent years, additional mechanisms have been recognized. These include angioblasts recruitment, cooption, vasculogenic mimicry and mosaic vessels. These different mechanisms may exist concomitantly in the same tumor or may be selectively involved in a specific tumor type or host environment. In this article, we will review, in depth, these different mechanisms and also discuss some aspects of anti-angiogenic tumor therapy.
肿瘤血管生成是血管生成研究和肿瘤生物学中一个快速发展的子领域。其基本机制已被阐明，许多关键因素也已被确定。多年来，肿瘤血管形成一直仅被解释为新血管从已有的血管向内长入肿瘤。然而，近年来，人们认识到了其他机制。这些机制包括成血管细胞募集、血管生成拟态、血管选择利用和镶嵌血管。这些不同的机制可能在同一肿瘤中同时存在，也可能选择性地参与特定的肿瘤类型或宿主环境。在本文中，我们将深入综述这些不同的机制，并讨论抗血管生成肿瘤治疗的一些方面。
