Lambert S B, O'Grady K F, Gabriel S H, Nolan T M
Murdoch Childrens Research Institute, Royal Children's Hospital, Australia.
J Paediatr Child Health. 2005 Mar;41(3):125-9. doi: 10.1111/j.1440-1754.2005.00561.x.
To examine the epidemiology and burden of respiratory illness during winter in urban children from temperate Australia.
We conducted a cohort study of healthy Melbourne children, aged from 12 to 71 months. Parents kept a daily respiratory symptom diary and recorded resource use when an influenza-like illness (ILI) occurred.
One-hundred and eighteen children had 137 ILI episodes over 12 weeks for a rate of 0.53 ILI episodes per child-month (95% CI 0.44-0.61). Risk factors for ILI included younger age, fewer people residing in the household, structured exposure to other children outside the home, and a higher household income. Episodes had a mean duration of 10.4 days with 64 visits to a general practitioner (46.7 GP visits per 100 episodes), 27 antibiotic courses prescribed (19.7 antibiotic courses per 100 episodes), and three overnight hospitalizations (2.2 admissions per 100 episodes). Parents reported an average of 11.7 h excess time spent caring for a child per episode.
Respiratory illnesses are a common and largely neglected cause of illness in Australian children. Pathogen-specific data are required to better assess the likely impact of available and developing vaccines and other treatment options.
研究澳大利亚温带地区城市儿童冬季呼吸道疾病的流行病学特征及疾病负担。
我们对12至71个月大的墨尔本健康儿童进行了一项队列研究。家长记录每日呼吸道症状日志,并在孩子出现流感样疾病(ILI)时记录资源使用情况。
118名儿童在12周内发生了137次ILI发作,发生率为每儿童月0.53次ILI发作(95%可信区间0.44 - 0.61)。ILI的危险因素包括年龄较小、家庭居住人数较少、在家外有组织地接触其他儿童以及家庭收入较高。发作的平均持续时间为10.4天,共看全科医生64次(每100次发作46.7次看全科医生),开具27个抗生素疗程(每100次发作19.7个抗生素疗程),3次过夜住院(每100次发作2.2次入院)。家长报告每次发作平均额外花费11.7小时照顾孩子。
呼吸道疾病是澳大利亚儿童常见且很大程度上被忽视的疾病病因。需要病原体特异性数据来更好地评估现有和正在研发的疫苗及其他治疗选择可能产生的影响。