镍催化仲烯丙基氯与烷基锌的不对称根岸交叉偶联反应。
Nickel-catalyzed asymmetric negishi cross-couplings of secondary allylic chlorides with alkylzincs.
作者信息
Son Sunghee, Fu Gregory C
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
J Am Chem Soc. 2008 Mar 5;130(9):2756-7. doi: 10.1021/ja800103z. Epub 2008 Feb 8.
PMID:18257579
Abstract
Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A1.
摘要
作为烯丙基化化学先前进展的补充，已开发出一种有效的镍/吡啶二酮催化剂，用于外消旋仲烯丙基氯与易得的有机锌卤化物的区域选择性不对称根岸交叉偶联反应。该方法已应用于氟维菌素A1形式全合成的两个关键步骤中。
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