Papadopoulos F C, Petridou E, Argyropoulou S, Kontaxakis V, Dessypris N, Anastasiou A, Katsiardani K P, Trichopoulos D, Lyketsos C
Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece.
Int J Geriatr Psychiatry. 2005 Apr;20(4):350-7. doi: 10.1002/gps.1288.
Depression in late life is common and has serious consequences on function, medical co-morbidity, quality of life, and use of medical services.
To estimate the age- and gender-specific prevalence of depression among people over 60 years of age, and to examine correlates of depression, in particular the relationship between depression and cognitive impairment.
From a total of 965 inhabitants, aged over 60 years, in Velestino, a rural town in central Greece, 608 were accessible and constituted the target population. During a five-month period in 2000, a trained health visitor interviewed all study participants. The interview covered socio-demographic characteristics, medical history, and administration of the 15-question Geriatric Depression Scale (GDS-15) and the Mini Mental Scale Examination instrument (MMSE).
The prevalence of mild or more severe depression (GDS> or =7) was 27%, while the prevalence of moderate to severe depression (GDS> or =11) was 12%. Increasing age, female gender, lower education, and being currently unmarried were associated with higher risk of depression in univariate regression models, but these associations disappeared after controlling for cognitive function, except for the association with marital status. Cognitive impairment was strongly associated with increased risk for depression. The co-morbid presence of digestive, neurological and heart conditions was also associated with increased risk for depression, while cancer was not.
In a rural Greek area, the prevalence of depression in late life is high. Depression was more common among unmarried individuals, those with significant cognitive impairment, and in association with specific medical conditions.
老年抑郁症很常见，会对功能、合并症、生活质量和医疗服务利用产生严重影响。
估计60岁以上人群中抑郁症的年龄和性别特异性患病率，并研究抑郁症的相关因素，特别是抑郁症与认知障碍之间的关系。
在希腊中部一个乡村小镇韦莱斯蒂诺的965名60岁以上居民中，608人可纳入研究并构成目标人群。2000年的五个月期间，一名经过培训的健康访视员对所有研究参与者进行了访谈。访谈内容包括社会人口学特征、病史，以及使用15项老年抑郁量表（GDS-15）和简易精神状态检查表（MMSE）进行评估。
轻度或更严重抑郁症（GDS≥7）的患病率为27%，而中度至重度抑郁症（GDS≥11）的患病率为12%。在单变量回归模型中，年龄增长、女性、教育程度较低和目前未婚与抑郁症风险较高相关，但在控制认知功能后，这些关联消失了，婚姻状况的关联除外。认知障碍与抑郁症风险增加密切相关。消化系统、神经系统和心脏疾病的合并存在也与抑郁症风险增加相关，而癌症则不然。
在希腊农村地区，老年抑郁症的患病率很高。抑郁症在未婚个体、有明显认知障碍的个体以及与特定疾病相关的人群中更为常见。
