Benhadou Farida, Mintoff Dillon, Schnebert Benjamin, Thio Hok Bing
Dermatology Department, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Brussels, Belgium.
Dermatology Department, Sir Paul Boffa Hospital, 1491 Floriana, Malta.
Diseases. 2018 Jun 2;6(2):47. doi: 10.3390/diseases6020047.
Recent advances have highlighted the crucial role of microbiota in the pathophysiology of chronic inflammatory diseases as well as its impact on the efficacy of therapeutic agents. Psoriasis is a chronic, multifactorial inflammatory skin disorder, which has a microbiota distinct from healthy, unaffected skin.
Through an extensive review of the literature, we aim to discuss the skin and gut microbiota and redefine their role in the pathogenesis of psoriasis.
Unfortunately, the direct link between the skin microbiota and the pathogenesis of psoriasis remains to be clearly established. Apart from improving the course of psoriasis, selective modulation of the microbiota may increase the efficacy of medical treatments as well as attenuate their side effects.
近期的进展凸显了微生物群在慢性炎症性疾病病理生理学中的关键作用及其对治疗药物疗效的影响。银屑病是一种慢性、多因素炎症性皮肤病，其微生物群与健康未受影响的皮肤不同。
通过广泛的文献综述，我们旨在讨论皮肤和肠道微生物群，并重新定义它们在银屑病发病机制中的作用。
遗憾的是，皮肤微生物群与银屑病发病机制之间的直接联系仍有待明确确立。除了改善银屑病病程外，对微生物群的选择性调节可能会提高药物治疗的疗效并减轻其副作用。
