Lafon Monique
Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 75724 Paris cedex 15, France.
J Neurovirol. 2005 Feb;11(1):82-7. doi: 10.1080/13550280590900427.
There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind rabies virus and/or facilitate rabies virus entry into cells. Other components of the cell membrane, such as gangliosides, may also participate in the entry of rabies virus. However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system.
有令人信服的体外证据表明，烟碱型乙酰胆碱受体（nAChR）的肌肉形式、神经元细胞粘附分子（NCAM）和p75神经营养因子受体（p75NTR）可结合狂犬病毒和/或促进狂犬病毒进入细胞。细胞膜的其他成分，如神经节苷脂，也可能参与狂犬病毒的进入过程。然而，这些分子在体内的作用却鲜为人知。本综述提出了一个推测性模型，解释了这些不同分子在狂犬病毒进入和在神经系统中运输过程中的作用。
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