Xu Ming-Feng, Shen Lian-Qing, Wang Kui-Wu, Du Qi-Zhen, Wang Nan
College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, China.
J Asian Nat Prod Res. 2011 Mar;13(3):260-4. doi: 10.1080/10286020.2010.550882.
A new abietane diterpenoid, (3S,16R)-12,16-epoxy-3,6,11,14,17-pentahydroxy-17(15 → 16)-abeo-5,8,11,13-abietatetraen-7-one (1), was isolated from the stems of Clerodendrum kaichianum Hsu, together with four known diterpenoids. The structures of the isolated compounds were assigned on the basis of their NMR spectra including 2D NMR techniques such as COSY, HMQC, and HMBC experiments, and were compared with those of the literature data. This new compound showed significant cytotoxicity against the HL-60 and A-549 tumor cell lines.
从海州常山（Clerodendrum kaichianum Hsu）的茎中分离出一种新的枞酸型二萜，即(3S,16R)-12,16-环氧-3,6,11,14,17-五羟基-17(15→16)-去甲-5,8,11,13-枞四烯-7-酮（1），同时还分离出四种已知的二萜。根据包括COSY、HMQC和HMBC实验等二维核磁共振技术的核磁共振光谱确定了分离出的化合物的结构，并与文献数据进行了比较。这种新化合物对HL-60和A-549肿瘤细胞系显示出显著的细胞毒性。
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