Birch C J, Clothier H J, Seccull A, Tran T, Catton M C, Lambert S B, Druce J D
Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia.
Epidemiol Infect. 2005 Apr;133(2):273-7. doi: 10.1017/s0950268804003346.
Three outbreaks of respiratory illness associated with human coronavirus HCoV-OC43 infection occurred in geographically unrelated aged-care facilities in Melbourne, Australia during August and September 2002. On clinical and epidemiological grounds the outbreaks were first thought to be caused by influenza virus. HCoV-OC43 was detected by RT-PCR in 16 out of 27 (59%) specimens and was the only virus detected at the time of sampling. Common clinical manifestations were cough (74%), rhinorrhoea (59%) and sore throat (53%). Attack rates and symptoms were similar in residents and staff across the facilities. HCoV-OC43 was also detected in surveillance and diagnostic respiratory samples in the same months. These outbreaks establish this virus as a cause of morbidity in aged-care facilities and add to increasing evidence of the significance of coronavirus infections.
2002年8月至9月期间，在澳大利亚墨尔本地理位置不相关的老年护理机构中发生了三起与人类冠状病毒HCoV-OC43感染相关的呼吸道疾病暴发。基于临床和流行病学依据，这些暴发最初被认为是由流感病毒引起的。通过逆转录聚合酶链反应（RT-PCR）在27份标本中的16份（59%）中检测到了HCoV-OC43，并且它是采样时唯一检测到的病毒。常见的临床表现为咳嗽（74%）、流涕（59%）和咽痛（53%）。各机构的居民和工作人员中的发病率及症状相似。在同一月份的监测和诊断性呼吸道样本中也检测到了HCoV-OC43。这些暴发证实了该病毒是老年护理机构中发病的一个原因，并进一步增加了冠状病毒感染重要性的证据。
