伊朗东北部地区口腔健康状况不佳作为食管鳞状上皮发育异常的一个风险因素
Poor oral health as a risk factor for esophageal squamous dysplasia in northeastern Iran.
作者信息
Sepehr Alireza, Kamangar Farin, Fahimi Saman, Saidi Farrokh, Abnet Christian C, Dawsey Sanford M
机构信息
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA.
出版信息
Anticancer Res. 2005 Jan-Feb;25(1B):543-6.
BACKGROUND
Northeastern Iran has one of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world. The reasons for observing such high rates of ESCC in this area are not fully clear. The current study evaluates the association between some potential risk factors and squamous dysplasia, a precursor lesion of ESCC, in northeastern Iran.
MATERIALS AND METHODS
Using logistic regression, we compared potential risk factors of ESCC in 124 individuals with dysplasia and 50 normal individuals from northeastern Iran. Case/control status was histologically proven in all 174 study participants.
RESULTS
Poor oral health showed a dose-response association with ESCC risk (p for trend < 0.01). Edentulous individuals had 5-fold higher risk of dysplasia compared to participants with good oral health (p-value < 0.01).
CONCLUSION
Our results are consistent with two other published studies that have shown oral health as a risk factor for ESCC. The high incidence of ESCC in northeastern Iran may be partly attributable to poor oral health.
背景
伊朗东北部是世界上食管鳞状细胞癌（ESCC）发病率最高的地区之一。该地区ESCC发病率如此之高的原因尚不完全清楚。本研究评估了伊朗东北部一些潜在风险因素与鳞状上皮发育异常（ESCC的一种前驱病变）之间的关联。
材料与方法
我们采用逻辑回归分析，比较了伊朗东北部124例发育异常个体和50例正常个体中ESCC的潜在风险因素。所有174名研究参与者的病例/对照状态均经组织学证实。
结果
口腔卫生状况差与ESCC风险呈剂量反应关系（趋势p值<0.01）。与口腔卫生良好的参与者相比，无牙个体发育异常的风险高5倍（p值<0.01）。
结论
我们的结果与另外两项已发表的研究一致，这两项研究均表明口腔卫生是ESCC的一个风险因素。伊朗东北部ESCC的高发病率可能部分归因于口腔卫生状况差。
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