Sorimachi K
Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
Cell Biol Int Rep. 1992 Mar;16(3):249-57. doi: 10.1016/s0309-1651(06)80126-8.
When cell lines derived from tumor tissues were plated simultaneously with the lignin derivative or dextran sulfate in plastic culture dishes, the cells did not completely adhere to dishes and/or the shape of even the adhering cells changed significantly. On the other hand, using cell lines derived from normal tissues, no significant effect of the polyanions was observed. The present study revealed that the lignin derivatives demonstrated differential responses between cells derived from tumor tissues and from normal tissues, and that the lignin derivatives strongly inhibited the growth of mouse sarcoma cells (FRUKTO) and rat foetal cells (Ad12-3Y1-Z19) transformed with adeno virus type 12.
当将源自肿瘤组织的细胞系与木质素衍生物或硫酸葡聚糖同时接种于塑料培养皿中时，细胞不能完全黏附于培养皿，和/或即使是已黏附细胞的形态也发生了显著变化。另一方面，对于源自正常组织的细胞系，未观察到这些聚阴离子有显著影响。本研究表明，木质素衍生物对源自肿瘤组织和正常组织的细胞表现出不同的反应，并且木质素衍生物强烈抑制用12型腺病毒转化的小鼠肉瘤细胞（FRUKTO）和大鼠胎儿细胞（Ad12 - 3Y1 - Z19）的生长。
