Cheung Fung Kei Kathy, Hayes Aidan M, Hannedouche Jerome, Yim Aveline S Y, Wills Martin
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
J Org Chem. 2005 Apr 15;70(8):3188-97. doi: 10.1021/jo050032a.
Stereochemically well-defined ruthenium(II) catalysts have been applied to the asymmetric transfer hydrogenation of a series of ketones. In one case, statistical experimental design was employed to optimize the enantiomeric excess of the product. In the case of the TsDPEN-based systems, the replacement of trans-1,2-diphenyl substitution with cis-, or deletion of one of the phenyl groups, results in significant deterioration of the enantiomeric excess. A new method is described for the synthesis of tethered amino alcohol-containing catalysts.
立体化学结构明确的钌（II）催化剂已应用于一系列酮的不对称转移氢化反应。在一个案例中，采用统计实验设计来优化产物的对映体过量。在基于TsDPEN的体系中，用顺式-1,2-二苯基取代反式-1,2-二苯基取代基，或去除其中一个苯基，会导致对映体过量显著下降。本文描述了一种合成含连接型氨基醇催化剂的新方法。
