大脑型惠普尔病作为可逆性痴呆的一个病因。

Cerebral Whipple's disease as a cause of reversible dementia.

作者信息

Rossi T, Haghighipour R, Haghighi M, Paolini S, Scarpino O

机构信息

Unità Operativa di Neurologia, Ospedale Geriatrico Sestilli, I.N.R.C.A., Ancona, Italy.

出版信息

Clin Neurol Neurosurg. 2005 Apr;107(3):258-61. doi: 10.1016/j.clineuro.2004.10.014.

DOI:10.1016/j.clineuro.2004.10.014

PMID:15823686

Abstract

We describe a case of reversible dementia caused by Tropheryma whippelii (TW). Diagnosis was confirmed by a positive polymerase chain reaction for this pathogen both on serum and cerebrospinal fluid. Specific antibiotic therapy resulted in distinct clinical and neuroradiological improvement. Control polymerase chain reaction for T. whippelii on serum and cerebrospinal fluid was negative.

摘要

我们描述了一例由惠普尔嗜组织细胞菌（TW）引起的可逆性痴呆病例。血清和脑脊液中该病原体的聚合酶链反应呈阳性，确诊了该病。特异性抗生素治疗使临床和神经放射学症状有明显改善。血清和脑脊液中惠普尔嗜组织细胞菌的聚合酶链反应对照结果为阴性。