Zhivotovsky L A, Feldman M W
Institute of General Genetics, Russian Academy of Sciences, Moscow.
Genetics. 1992 Apr;130(4):947-55. doi: 10.1093/genetics/130.4.947.
A model of stabilizing selection on a multilocus character is proposed that allows the maintenance of stable allelic polymorphism and linkage disequilibrium. The model is a generalization of Lerner's model of homeostasis in which heterozygotes are less susceptible to environmental variation and hence are superior to homozygotes under phenotypic stabilizing selection. The analysis is carried out for weak selection with a quadratic-deviation model for the stabilizing selection. The stationary state is characterized by unequal allele frequencies, unequal proportions of complementary gametes, and a reduction of the genetic (and phenotypic) variance by the linkage disequilibrium. The model is compared with Mather's polygenic balance theory, with models that include mutation-selection balance, and others that have been proposed to study the role of linkage disequilibrium in quantitative inheritance.
提出了一个关于多基因座性状的稳定选择模型，该模型能够维持稳定的等位基因多态性和连锁不平衡。此模型是对勒纳稳态模型的推广，在该模型中，杂合子对环境变异的敏感度较低，因此在表型稳定选择下优于纯合子。采用二次偏差模型对弱选择下的稳定选择进行分析。稳态的特征是等位基因频率不等、互补配子比例不等，以及连锁不平衡导致遗传（和表型）方差减小。将该模型与马瑟的多基因平衡理论、包含突变 - 选择平衡的模型以及其他为研究连锁不平衡在数量遗传中的作用而提出的模型进行了比较。
