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GP treatment decisions for patients with depression: an observational study.全科医生对抑郁症患者的治疗决策:一项观察性研究。
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Can the Use of Bayesian Analysis Methods Correct for Incompleteness in Electronic Health Records Diagnosis Data? Development of a Novel Method Using Simulated and Real-Life Clinical Data.贝叶斯分析方法能否纠正电子健康记录诊断数据中的不完整性?使用模拟和真实临床数据开发一种新方法。
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本文引用的文献

1
Secular trends in antidepressant prescribing in the UK, 1975-1998.1975 - 1998年英国抗抑郁药处方的长期趋势。
J Public Health Med. 2001 Dec;23(4):262-7. doi: 10.1093/pubmed/23.4.262.
2
Hampshire depression project: changes in the process of care and cost consequences.汉普郡抑郁症项目:护理过程的变化及成本后果
Br J Gen Pract. 2001 Nov;51(472):911-3.
3
Influence of socio-economic deprivation on the prevalence and outcome of depression in primary care: the Hampshire Depression Project.社会经济剥夺对初级保健中抑郁症患病率及治疗结果的影响:汉普郡抑郁症项目
Br J Psychiatry. 2001 Jan;178(1):12-7. doi: 10.1192/bjp.178.1.12.
4
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. British Association for Psychopharmacology.基于证据的抗抑郁药治疗抑郁症指南:1993年英国精神药理学会指南修订版。英国精神药理学会
J Psychopharmacol. 2000 Mar;14(1):3-20. doi: 10.1177/026988110001400101.
5
Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial.临床实践指南及基于实践的教育对基层医疗中抑郁症检测及转归的影响:汉普郡抑郁症项目随机对照试验
Lancet. 2000 Jan 15;355(9199):185-91. doi: 10.1016/s0140-6736(99)03171-2.
6
Why can't GPs follow guidelines on depression? We must question the basis of the guidelines themselves.为什么全科医生不能遵循抑郁症指南?我们必须质疑这些指南本身的依据。
BMJ. 2000 Jan 22;320(7229):200-1. doi: 10.1136/bmj.320.7229.200.
7
Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines.英国初级医疗中抗抑郁药处方的纵向模式:与治疗指南的比较。
J Psychopharmacol. 1999;13(2):136-43. doi: 10.1177/026988119901300204.
8
Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial.抗抑郁药物咨询及宣传册对基层医疗中药物治疗依从性的影响:随机对照试验
BMJ. 1999 Sep 4;319(7210):612-5. doi: 10.1136/bmj.319.7210.612.
9
The quantity and quality of clinical practice guidelines for the management of depression in primary care in the UK.英国初级保健中抑郁症管理临床实践指南的数量和质量。
Br J Gen Pract. 1999 Mar;49(440):205-10.
10
The underrecognition and undertreatment of depression: what is the breadth and depth of the problem?抑郁症的认识不足与治疗不足:问题的广度和深度如何?
J Clin Psychiatry. 1999;60 Suppl 7:4-9; discussion 10-1.

全科医生对抑郁症患者的治疗决策:一项观察性研究。

GP treatment decisions for patients with depression: an observational study.

作者信息

Kendrick Tony, King Fiona, Albertella Louise, Smith Peter Wf

机构信息

Division of Community Clinical Sciences, School of Medicine, University of Southampton.

出版信息

Br J Gen Pract. 2005 Apr;55(513):280-6.

PMID:15826435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463130/
Abstract

BACKGROUND

GPs are prescribing more antidepressants than previously, but not in accordance with guidelines. The reasons why they prescribe are not well understood.

AIM

To explore associations between GP treatment and severity of depression, patients' life difficulties, previous history of illness and treatment, and patient attitudes.

DESIGN

Observational study in two phases, 3 years apart.

SETTING

Seven practices in Southampton, UK.

METHOD

Adult attenders who consented were screened for depression in the waiting room. After the consultation, the 17 participating GPs completed questionnaires on the perceived presence and severity of depression, patients' life difficulties, previous problems and treatment, patient attitudes towards antidepressants, and their treatment decisions. Patients returned postal questionnaires on sociodemographics, life events, physical health, and attitudes towards antidepressants.

RESULTS

Of 694 patients screened in the two phases, the GPs rated 101 (15%) as depressed, acknowledged depression in 44 cases (6%), and offered treatment in 27 (4%), including antidepressants in 14 (2%). Offers of antidepressants were more likely in both phases where the GPs rated the depression as moderate rather than mild, and where they perceived a positive patient attitude to antidepressants. However, GP ratings of severity did not agree well with the validated screening instrument, and their assessments of patients' attitudes to treatment were only moderately related to patients' self-reports.

CONCLUSIONS

In line with current guidelines, GPs base prescribing decisions on the perceived severity of depression, taking patients' preferences into account, but they do not accurately identify which patients are likely to benefit from treatment. Better ways to assess depression severity and patient attitudes towards antidepressants are needed in order to target treatment more appropriately.

摘要

背景

全科医生开具的抗抑郁药比以前更多,但并不符合指南。他们开药的原因尚不清楚。

目的

探讨全科医生的治疗与抑郁症严重程度、患者生活困难、既往病史和治疗情况以及患者态度之间的关联。

设计

分两个阶段进行的观察性研究,间隔3年。

地点

英国南安普敦的7家诊所。

方法

在候诊室对同意参与的成年就诊者进行抑郁症筛查。会诊后,17名参与的全科医生填写问卷,内容包括对抑郁症的感知存在和严重程度、患者生活困难、既往问题和治疗情况、患者对抗抑郁药的态度以及他们的治疗决定。患者通过邮寄问卷反馈社会人口统计学、生活事件、身体健康以及对抗抑郁药的态度等信息。

结果

在两个阶段筛查的694名患者中,全科医生将101名(15%)评定为抑郁,确认44例(6%)患有抑郁症,并为27例(4%)提供了治疗,其中14例(2%)使用了抗抑郁药。在两个阶段中,如果全科医生将抑郁症评定为中度而非轻度,以及他们认为患者对抗抑郁药持积极态度,那么提供抗抑郁药治疗的可能性更大。然而,全科医生对严重程度的评定与经过验证的筛查工具的评定结果不太一致,他们对患者治疗态度的评估与患者的自我报告仅具有中等相关性。

结论

与当前指南一致,全科医生根据对抑郁症严重程度的感知以及患者的偏好来做出开药决定,但他们不能准确识别哪些患者可能从治疗中获益。需要更好的方法来评估抑郁症严重程度和患者对抗抑郁药的态度,以便更恰当地进行治疗。