Kendrick Tony, King Fiona, Albertella Louise, Smith Peter Wf
Division of Community Clinical Sciences, School of Medicine, University of Southampton.
Br J Gen Pract. 2005 Apr;55(513):280-6.
GPs are prescribing more antidepressants than previously, but not in accordance with guidelines. The reasons why they prescribe are not well understood.
To explore associations between GP treatment and severity of depression, patients' life difficulties, previous history of illness and treatment, and patient attitudes.
Observational study in two phases, 3 years apart.
Seven practices in Southampton, UK.
Adult attenders who consented were screened for depression in the waiting room. After the consultation, the 17 participating GPs completed questionnaires on the perceived presence and severity of depression, patients' life difficulties, previous problems and treatment, patient attitudes towards antidepressants, and their treatment decisions. Patients returned postal questionnaires on sociodemographics, life events, physical health, and attitudes towards antidepressants.
Of 694 patients screened in the two phases, the GPs rated 101 (15%) as depressed, acknowledged depression in 44 cases (6%), and offered treatment in 27 (4%), including antidepressants in 14 (2%). Offers of antidepressants were more likely in both phases where the GPs rated the depression as moderate rather than mild, and where they perceived a positive patient attitude to antidepressants. However, GP ratings of severity did not agree well with the validated screening instrument, and their assessments of patients' attitudes to treatment were only moderately related to patients' self-reports.
In line with current guidelines, GPs base prescribing decisions on the perceived severity of depression, taking patients' preferences into account, but they do not accurately identify which patients are likely to benefit from treatment. Better ways to assess depression severity and patient attitudes towards antidepressants are needed in order to target treatment more appropriately.
全科医生开具的抗抑郁药比以前更多,但并不符合指南。他们开药的原因尚不清楚。
探讨全科医生的治疗与抑郁症严重程度、患者生活困难、既往病史和治疗情况以及患者态度之间的关联。
分两个阶段进行的观察性研究,间隔3年。
英国南安普敦的7家诊所。
在候诊室对同意参与的成年就诊者进行抑郁症筛查。会诊后,17名参与的全科医生填写问卷,内容包括对抑郁症的感知存在和严重程度、患者生活困难、既往问题和治疗情况、患者对抗抑郁药的态度以及他们的治疗决定。患者通过邮寄问卷反馈社会人口统计学、生活事件、身体健康以及对抗抑郁药的态度等信息。
在两个阶段筛查的694名患者中,全科医生将101名(15%)评定为抑郁,确认44例(6%)患有抑郁症,并为27例(4%)提供了治疗,其中14例(2%)使用了抗抑郁药。在两个阶段中,如果全科医生将抑郁症评定为中度而非轻度,以及他们认为患者对抗抑郁药持积极态度,那么提供抗抑郁药治疗的可能性更大。然而,全科医生对严重程度的评定与经过验证的筛查工具的评定结果不太一致,他们对患者治疗态度的评估与患者的自我报告仅具有中等相关性。
与当前指南一致,全科医生根据对抑郁症严重程度的感知以及患者的偏好来做出开药决定,但他们不能准确识别哪些患者可能从治疗中获益。需要更好的方法来评估抑郁症严重程度和患者对抗抑郁药的态度,以便更恰当地进行治疗。