Wong C W, Seow W K, Thong Y H
Department of Child Health, University of Queensland, Mater Childrens Hospital, South Brisbane, Australia.
Int Arch Allergy Immunol. 1992;97(1):31-6. doi: 10.1159/000236092.
The effects of the bisbenzylisoquinoline alkaloids tetrandrine and berbamine on experimental allergic encephalitis (EAE) in Lewis rats was investigated. Amelioration of the acute-phase EAE was only minimal. However, the incidence of relapsing EAE was reduced by 41 and 65% for tetrandrine and berbamine, respectively, at the non-toxic treatment schedule of 60 mg/kg administered on alternate days. These results suggest that bisbenzylisoquinoline compounds may have a potential role in the therapy of progressive multiple sclerosis.
研究了双苄基异喹啉生物碱粉防己碱和小檗胺对Lewis大鼠实验性变应性脑脊髓炎（EAE）的影响。急性期EAE的改善程度很小。然而，在每隔一天给予60mg/kg的无毒治疗方案下，粉防己碱和小檗胺使复发性EAE的发生率分别降低了41%和65%。这些结果表明，双苄基异喹啉化合物可能在进行性多发性硬化症的治疗中具有潜在作用。
