Zwadlo-Klarwasser G, Neubert R, Stahlmann R, Schmutzler W
Institute of Pharmacology, Medical Faculty, RWTH Aachen, FRG.
Int Arch Allergy Immunol. 1992;97(2):178-80. doi: 10.1159/000236115.
Subcutaneous injection of the glucocorticoid dexamethasone in the primate Callithrix jacchus increased the proportion of the macrophage subtype RM 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. The elevated numbers of RM 3/1-positive cells were seen 24 and 72 h after application and were independent of the dosages used (50 or 150 micrograms/kg). Oral administration had no effect. CD4-, CD14- and CDw14-antigen expression of monocytes was not influenced by the dexamethasone treatment. In tissues, e.g. spleen, thymus, liver, skin and kidney, RM 3/1-positive macrophages revealed a similar distribution as in human tissues but no differences in glucocorticoid treated to control animals could be observed. These results show that glucocorticoids induce in the monkey Callithrix jacchus a distinct monocyte subtype similarly as in man while other macrophage phenotypes were not influenced.
在灵长类动物普通狨猴中皮下注射糖皮质激素地塞米松，可使血液中巨噬细胞亚型RM 3/1的比例从16%的基础阳性单核细胞水平增加到约65%。给药后24小时和72小时可见RM 3/1阳性细胞数量增加，且与所用剂量（50或150微克/千克）无关。口服给药无效果。地塞米松处理对单核细胞的CD4、CD14和CDw14抗原表达没有影响。在脾脏、胸腺、肝脏、皮肤和肾脏等组织中，RM 3/1阳性巨噬细胞的分布与人类组织相似，但在糖皮质激素处理组和对照组动物之间未观察到差异。这些结果表明，糖皮质激素在普通狨猴中诱导出一种与人类相似的独特单核细胞亚型，而其他巨噬细胞表型未受影响。
