Arinaga S, Karimine N, Takamuku K, Nanbara S, Nagamatsu M, Ueo H, Akiyoshi T
Department of Surgery, Kyushu University, Beppu, Japan.
Int J Immunopharmacol. 1992 Jan;14(1):43-7. doi: 10.1016/0192-0561(92)90103-r.
The effect of intravenous administration of lentinan, an immunopotentiating polysaccharide, on the production of interleukin 1-alpha (IL 1-alpha), interleukin 1-beta (IL 1-beta) and tumor necrosis factor-alpha (TNF-alpha) by monocytes in peripheral blood mononuclear cells (PBM) was studied in patients with gastric carcinoma. Peripheral blood samples were obtained from 10 patients before and 3, 5 and 7 days after a single dose of 2 mg lentinan injection. The ability of monocytes in PBM to produce IL 1-alpha was significantly augmented 3 and 5 days after lentinan administration, as compared with that before treatment. IL 1-beta production was also significantly increased 3, 5 and 7 days after the drug injection. Further, the capacity to produce TNF-alpha was significantly enhanced 3, 5 and 7 days after the drug administration. Thus, it is likely that the augmentation of these cytokine's production may contribute to the antitumor action of lentinan in patients with gastric carcinoma.
在胃癌患者中研究了静脉注射香菇多糖（一种免疫增强多糖）对人外周血单个核细胞（PBM）中单核细胞产生白细胞介素1-α（IL 1-α）、白细胞介素1-β（IL 1-β）和肿瘤坏死因子-α（TNF-α）的影响。在10例患者单次注射2mg香菇多糖前及注射后3、5和7天采集外周血样本。与治疗前相比，香菇多糖给药后3天和5天，PBM中单核细胞产生IL 1-α的能力显著增强。药物注射后3、5和7天，IL 1-β的产生也显著增加。此外，给药后3、5和7天，产生TNF-α的能力显著增强。因此，这些细胞因子产生的增加可能有助于香菇多糖对胃癌患者的抗肿瘤作用。
